Liquid chromatography—mass applications

Brown, M.A., Liquid Chromatography/Mass Spectrometry Applications in Agricultural, Pharmaceutical and Environmental Chemistry, Oxford University Press, Oxford, 1998. 

Yergey, A.L., Edmonds, C.G., Lewis, I.A.S., and Vestal, M.L., Liquid Chromatography/Mass Spectrometry Techniques and Applications, Plenum Press, New York, 1990. 

Very little in the way of advances has occurred since 1971 in the applications of ultraviolet or infrared spectroscopy to the analysis of fluonnated organic compounds Therefore, only gas-liquid chromatography, liquid chromatography, mass spectrometry, and electron scattering for chemical analysis (ESCA) are discussed The application of nuclear magnetic resonance (NMR) spectroscopy to the analysis of fluonnated organic compounds is the subject of another section of this chapter... 

Applications of High Performance Liquid Chromatography-Mass Spectrometry... 

Barcelo D. 1988. Application of thermospray liquid chromatography/mass spectrometry for determination of organophosphoms pesticides and trialkyl and triaryl phosphates. Biomed Environ Mass Spectrom 17 363-369. 

Several determination methods such as GC, HPLC, gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) are used for the analysis of neonicotinoid residues. The applications of GC/MS and LC/MS are of increasing importance. The application of HPLC to the determination of neonicotinoids residues is limited, especially when metabolites (such as acetamiprid and nitenpyram) can be easily determined by GC after derivatization. 

Vestel, "Liquid Chromatography/Mass Spectrometry. Techniques and Applications", Plenum Press, New York, NY, 1989. 

Nagele, E., Vollmer, M., Horth, P. (2003). Two-dimensional nano-liquid chromatography— mass spectrometry system for applications in proteomics. J. Chromatogr. A1009,197-205. 

Sanz-Nebot, V., Benavente, F., Barbosa, J. (2002). Liquid chromatography-mass spectrometry and capillary electrophoresis combined approach for separation and characterization of multicomponent peptide mixtures application to crude products of leuprolide synthesis. J. Chromatogr. A 950, 99-111. 

Xu, R. et al. 2002. Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries. J. Am. Soc. Mass Spectrom. 13 155. 

J. N. Damico and R. P. Barron. Application of Field Ionization to Gas-Liquid Chromatography-Mass Spectrometry (GLC-MS) Studies. Anal. Chem., 43(1971) 17-21. 

P. Arpino. Combined Liquid Chromatography Mass Spectrometry. III. Applications of Thermospray. Mass Spectrom. Rev., 11(1992) 3-40. 

R.D. Voyksner, C.S. Smith and P.C. Knox, Optimization and application of particle beam high-performance liquid chromatography/mass spectrometry to compounds of pharmaceutical interest, Biomed. Environ. Mass Spectrom., 19 (1990) 523-534. 

The different ways a particle beam liquid chromatography mass spectrometer can be configured reflect the versatility of the system in accommodating both the application and the availability of existing instrumentation. The system consists of these elements ... 

In Chapter 12, the use of mass spectrometry and Fourier transform infrared spectrometry (FTIR) for GC detection was discussed. Details of these techniques were individually given in Chapters 10 and 12. Much of the discussion presented in Chapter 16 is applicable here. Both liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-infrared spectrometry (LC-IR) have been adapted to HPLC detection in recent years. 

S. Perez-Magarino, I. Revilla, M.L. Gonzalez-SanJose and S.Beltran, Various applications of liquid chromatography-mass spectrometry to the analysis of phenolic compounds. J. Chromatogr.A, 847 (1999)75-81. 

Nowadays, ESI is the leading member of the group of atmospheric pressure ionization (API) methods and the method of choice for liquid chromatography-mass spectrometry coupling (LC-MS, Chap. 12). [10-13] Currently, ESI and MALDI (Chap. 10) are the most commonly employed ionization methods and they opened doors to the widespread biological and biomedical application of mass spectrometry. [5,10,11,13-17] Moreover, ESI serves well for the analysis of ionic metal complexes [18,19] and other inorganic analytes. [20-22]... 

Mordehai, A., Lim, H. K., and Henion, J. D. (1995). Ion-spray liquid-chromatography mass-spectrometry and capillary electrophoresis mass-spectrometry on a modified benchtop ion-trap mass-spectrometer. In Practical Aspects of Ion-Trap Mass Spectrometry Chemical, Environmental and Biomedical Applications (R. E. March, and J. F. J. Todd, Eds), Vol. 3, pp. 215—237, CRC Press, Boca Raton, FL. 

J. W. Hirschelman, W. H. et ah Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry application to resveratrol absorption and metabolism. Comb Chem High Throughput Screen 2003, 6, 757-767. 

Important progress in terms of higher throughput in ADME/PK work was realized recently by wider use of liquid chromatography/mass spectrometry (LC/MS), which has now become a standard analytical tool [26]. Flow NMR spectroscopy has become a routine method to resolve and identify mixtures of compounds and has found applications in drug metabolism and toxicology studies [27]. 

F. Baumann and R. Preiss, Application of liquid chromatography-mass spectrometry in the determination of oxazaphosphorines and their metabolites. Analytica Chimica Acta, 2003,492(1-2), 147-156. 

W.M.A. Niessen, J. Van der Greef, Liquid Chromatography-Mass Spectrometry Principles and Applications, Marcel Dekker, Inc., New York, 1992, p. 157. 

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