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Ligand receptors

In an extensive SFA study of protein receptor-ligand interactions, Leckband and co-workers [114] showed the importance of electrostatic, dispersion, steric, and hydrophobic forces in mediating the strong streptavidin-biotin interaction. Israelachvili and co-workers [66, 115] have measured the Hamaker constant for the dispersion interaction between phospholipid bilayers and find A = 7.5 1.5 X 10 erg in water. [Pg.247]

Agonist An agonist is a receptor ligand mediating a receptor response (intrinsic effect). [Pg.599]

Antagonist An antagonist is a receptor ligand preventing the action of an agonist, in a direct (competitive) or indirect (allosteric) manner. [Pg.599]

Kubinyi H1998. Structure-based Design of Enzyme Inhibitors and Receptor Ligands. Current Opinion i. Drug Discovery and Development 1 5-15. [Pg.739]

Nonbenzodiazepine Benzodiazepine Receptor Ligands. The simultaneous discovery of the molecular target for the BZs, the GABA /BZ receptor complex, by two teams of workers (34,35) resulted ia the identification of a number of atypical or anxioselective anxiolytics that, whereas not having the BZ pharmacophore, interacted direcdy with the central BZ receptor. The anxioselective nature of such agents was considered to be... [Pg.540]

Newel experimental approaches to anxiety therapy include ligands interacting with the ligand-gated ion channels that are selectively activated by nicotine, C qH 4N2 (87), the well-known active ingredient of cigarettes which has anxiolytic actions (42). Cholecystokinin B receptor ligands, specifically the dipeptoid, CI-988 [130404-91 -0] 02 1142 40 (88) have demonstrated anxiolytic activity ia preclinical models (43). [Pg.542]

The BZ stmcture also has provided a molecular scaffold for a number of peptide receptor ligands (26). Antagonists for the cholecystokinin (CCK-A) receptor, eg, devazepide (65), the thyrotropin-releasing hormone (TRH) receptor, eg, midazolam (66), and the /i -opiate receptor, eg, tifluadom (67), as well as a series of ras famyl transferase inhibitors, eg, BZA-2B (68) (30) have been identified (Table 4). [Pg.530]

CB, was identified by radioligand binding techniques and subsequently cloned. A second receptor subclass, CB2, has been identified in human spleen and also has been cloned (34). Table 5 Hsts cannabinoid receptor ligands. [Pg.532]

CJ-Receptors are localized ia the brain stem and limbic stmcture, regions associated with endocrine function (76). In the periphery, CJ-receptors are found in the Hver, heart, ileum, vas deferens, and on lymphocytes and thymocytes. Although there is insufficient evidence to clearly define the functional role of CNS CJ-sites, based on the effects of PCP and the interaction of haloperidol with CJ-sites, CJ-receptor ligands may be antipsychotics or used for the treatment of substance abuse. Several CJ-receptor ligands have shown neuroprotective effects in vivo. Ifenprodil (315) and CNS 1102 (316) are being developed for treatment of stroke (Table 18). [Pg.574]

The introduction of tritium into molecules is most commonly achieved by reductive methods, including catalytic reduction by tritium gas, PH2], of olefins, catalytic reductive replacement of halogen (Cl, Br, or I) by H2, and metal pH] hydride reduction of carbonyl compounds, eg, ketones (qv) and some esters, to tritium-labeled alcohols (5). The use of tritium-labeled building blocks, eg, pH] methyl iodide and pH]-acetic anhydride, is an alternative route to the preparation of high specific activity, tritium-labeled compounds. The use of these techniques for the synthesis of radiolabeled receptor ligands, ie, dmgs and dmg analogues, has been described ia detail ia the Hterature (6,7). [Pg.438]

In an approach to opioid receptor ligands,diazabicyclononanones were prepared in a double Petrenko-Kritschenko reaction. Diester 76, in the presence of methylamine and aryl aldehydes, was converted to piperidone 77. This was immediately resubmitted to the reaction conditions however, in this iteration formaldehyde replaced the aryl aldehyde component. The outcome of this reaction produced 78 which was further investigated for its use in rheumatoid arthritis. [Pg.313]

Biotinyl diazirine photophore for probing receptor-ligand 98H(47)625. [Pg.230]


See other pages where Ligand receptors is mentioned: [Pg.1709]    [Pg.96]    [Pg.611]    [Pg.141]    [Pg.141]    [Pg.142]    [Pg.220]    [Pg.541]    [Pg.21]    [Pg.517]    [Pg.520]    [Pg.525]    [Pg.528]    [Pg.528]    [Pg.532]    [Pg.553]    [Pg.572]    [Pg.573]    [Pg.240]    [Pg.259]    [Pg.271]    [Pg.282]    [Pg.380]    [Pg.382]    [Pg.205]    [Pg.234]    [Pg.237]    [Pg.181]    [Pg.182]    [Pg.352]    [Pg.354]    [Pg.355]    [Pg.364]    [Pg.365]    [Pg.105]    [Pg.85]   
See also in sourсe #XX -- [ Pg.259 ]

See also in sourсe #XX -- [ Pg.28 , Pg.29 , Pg.30 , Pg.31 , Pg.32 , Pg.33 , Pg.34 , Pg.35 , Pg.36 , Pg.37 , Pg.38 , Pg.39 , Pg.40 , Pg.41 , Pg.43 ]

See also in sourсe #XX -- [ Pg.157 ]

See also in sourсe #XX -- [ Pg.380 ]




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5-HT2A receptor ligand

5-HTja receptor ligands

Acetylcholine receptor ligands

Adenosine receptor ligands

Adenosine receptor ligands Adenylyl cyclase

Adenosine receptors selective ligands

Androstane receptor ligands

Angiotensin receptors ligands

Angiotensine receptor ligands

Antagonists benzodiazepine receptor ligands

Aryl hydrocarbon receptor ligands

Association constants, receptor-ligand interaction

Association constants, receptor-ligand interaction determination

Benzodiazepine receptor ligands

Benzodiazepine receptors endogenous ligands

Benzodiazepine receptors plant ligands

Binding, receptor/ligand autocrine growth factor

Binding, receptor/ligand diffusion

Binding, receptor/ligand membrane-associated molecules

Biosensors ligand-receptor interactions

CANCER METASTASIS Ligand-receptor interaction

CNS Receptor Ligands

Cannabinoid receptor ligands

Cannabinoid receptor ligands groups

Cannabinoid receptor ligands structures

Cell cycle protein modulation ligand receptor binding

Cell membrane receptor-ligand

Cell membrane, receptor/ligand binding

Cell surface receptors and their ligands

Cell surface, receptor/ligand binding

Characterization of the Receptor-Ligand Interaction

Chemokine receptors ligand structure

Chemokines receptor-ligand interactions

Chimeric peptides receptor ligands

Cholecystokinin receptor ligands

Complexation receptor-ligand

Computer simulation receptor/ligand studies

Constitutive androstane receptor ligands

Corticotrophin-releasing factor receptor ligands

Coupling receptor/ligand studies

Covalent bonds receptor-ligand

Death receptors, ligands

Delta opioid receptor ligands

Description of Scoring Functions for Receptor-Ligand Interactions

Dopaminergic ligand-receptor system

Endocytosis receptor-mediated ligand degradation

Endogenous opioid receptor ligand

Energy ligand-receptor interaction

Epidermal growth factor receptor ligand binding

Epidermal growth factor receptor ligand-induced dimerization

Epidermal growth factor receptor ligand-induced signaling

Epidermal growth factor receptor ligands

ErbB receptors ligands

Estrogen receptor ligands

Examples Ligand-Receptor Docking

Fluorescence methods ligand-receptor binding

Folate receptor ligands

Formyl peptide receptor ligand binding

Functional Orthogonality ligand-receptor pair

Functional models used to study dopamine receptor ligands

Functionalized ligand-receptor

G-protein-coupled receptors ligands

GABA receptor ligand

GABA-A receptor ligands

GABAa receptor ligands

Geometry ligand-receptor interactions

Glucocorticoid receptor ligand-binding domain

Glucocorticoid receptor ligands

Glycoproteins receptor ligands

Hemoglobin (ligand:receptor interaction

High ligand-receptor interactions

High-affinity ligand/receptor

High-affinity ligand/receptor complex

Histamine H3-Receptor Ligands

Homodimers as receptors ligands

Hormone receptor ligand-binding domains

Hydroxylation ligand-receptor interactions

Identical twin drugs receptor ligands

Imidazoline receptor ligands

Immunoglobulin receptor ligands

Insulin receptor ligands

Interaction between the ligand and receptor

Interactions, protein receptor-ligand

Ionotropic Receptors (Ligand-Gated Ion Channels)

Ionotropic glutamate receptors ligand binding

Ionotropic receptors (ligand-gated ion

Kinetics receptor/ligand binding

Lectins receptor ligands

Libraries receptor-ligand interactions

Ligand affinity agonist-receptor binding, dissociation

Ligand affinity nicotinic acetylcholine receptor

Ligand affinity receptor protein, binding site

Ligand anti-receptor study

Ligand binding adrenergic receptors

Ligand binding histamine receptors

Ligand binding muscarinic receptors

Ligand binding neuropeptide receptors

Ligand binding nicotinic receptors

Ligand binding receptor spheres

Ligand binding receptor-based

Ligand critical interaction with receptor

Ligand dimeric receptor state

Ligand dopamine receptor

Ligand properties receptor interactions

Ligand protein receptors

Ligand receptor binding studies

Ligand receptor recognition

Ligand receptor-bound conformation

Ligand-Olfactory Receptor Modelling

Ligand-activated nuclear receptor

Ligand-binding domains receptor tyrosine kinases

Ligand-bound nuclear hormone receptor

Ligand-gated channels receptor

Ligand-gated glutamate receptors

Ligand-gated ion-channel receptor

Ligand-receptor Binding Surface

Ligand-receptor analysis

Ligand-receptor association

Ligand-receptor chemistry

Ligand-receptor combination

Ligand-receptor dynamics, model

Ligand-receptor engagement

Ligand-receptor interaction kinetics

Ligand-receptor interaction, cellular

Ligand-receptor interaction, cellular communication

Ligand-receptor interaction-induced

Ligand-receptor interaction-induced functional effects

Ligand-receptor interactions

Ligand-receptor interactions affinity

Ligand-receptor interactions analysis

Ligand-receptor interactions cellular responses

Ligand-receptor interactions complex

Ligand-receptor interactions molecular modeling

Ligand-receptor interactions molecules

Ligand-receptor interactions stereoselectivity

Ligand-receptor interactions, computational

Ligand-receptor interactions, computational approach

Ligand-receptor interactions, specific

Ligand-receptor interactions, specific sites

Ligand-receptor relationships

Ligand-receptor structures

Ligand-receptor-G protein

Ligands and Receptors Involved in Platelet Aggregation

Ligands interaction with receptors

Ligands of Nuclear Receptors

Ligands peroxisome proliferator-activated receptor

Ligands receptor/ligand binding

Models receptor/ligand binding kinetics

Molecular ligand-receptor binding

Molecular ligand-receptor complex

Molecular ligand-receptor interaction

Multiple receptor ligands

Muscarinic cholinergic receptor ligands

NAChR receptor ligand binding domains

Neuroleptics ligand receptor binding studies

Neuronal receptors ligand receptor complex

Neuropeptide Y receptor ligand

Nicotinic acetylcholine receptor ligands

Nomenclature System for Chemokine Ligands and Receptors

Non-steroid cytosolic hormone receptor ligands

Novel Glucocorticoid Receptor Ligands

Nuclear hormone receptors ligand-binding domains

Nuclear receptor Ligand binding domain

Nuclear receptor Ligands

One Receptor-Two Ligands, Stochastic Kinetic Analysis

Opiate receptor ligands

Opioid receptor ligands

Opioid receptors ligand binding model

Orthogonal ligand-receptor pairs

Peptide receptors ligands

Peroxisome Proliferator-Activated Receptor y Ligands

Peroxisome proliferator-activated receptors PPARs), fatty acid ligands

Photolysis of the receptor-ligand complex

Potential dopamine receptor ligand

Pregnane X receptor ligands

Prostanoid receptors selective ligands and structure-activity relationships

Radioligands ligand-receptor interactions

Receptor Mutation and Ligand Modification

Receptor activator of NF-kB ligand

Receptor activator of nuclear factor-kB ligand

Receptor and Ligand Equilibria

Receptor binding peptide ligands

Receptor dimerization, ligand-driven

Receptor ligand gated

Receptor ligand layer

Receptor ligands endogenous

Receptor ligands for

Receptor ligands, QSAR

Receptor ligands, deconvolution

Receptor superfamilies extracellular ligand binding domains

Receptor tyrosine kinases ligand-induced dimerization

Receptor- and Ligand-Functionalized QDs for Sensing

Receptor-ligand binding

Receptor-ligand binding assay

Receptor-ligand binding interactions

Receptor-ligand binding interactions equilibrium thermodynamics

Receptor-ligand binding parameters

Receptor-ligand binding reactions

Receptor-ligand binding specific

Receptor-ligand complex

Receptor-ligand interaction screening

Receptor-ligand interactions defining

Receptor-ligand interactions, affinity capillary electrophoresis

Receptor-ligand interface

Receptor-ligand mimetics

Receptor-ligand-binding process

Receptor/ligand assays

Receptor/ligand pairs

Receptors activated solely by synthetic ligands

Receptors ancillary ligand

Retinoic acid receptor ligand binding domain

Retinoic acid receptor ligands

Retinoid X receptors specific ligands

Retinoid receptors ligand-binding assay

Retinoid receptors ligand-binding pocket

Retinoid receptors ligand-receptor interaction

Scoring Functions - Methods to Estimate Ligand-Receptor Binding

Selective delta receptor ligand

Serotonergic receptor ligand

Serotonin receptor ligands

Sialic Acid The Viral Cell-Surface Receptor Ligand

Sialyl receptor ligands

Sigma receptor ligands

Single ligand-receptor interaction

Solution, receptor/ligand binding

Steroid hormone receptors ligand structures

Structural Determinants of Ligand Binding and Receptor Activation by CC Chemokines

Surface Receptors and their Ligands

The Chemokine Supergene Families of Ligands and Receptors

The Relationship between Ligand Concentration and Receptor Occupancy

Thyroid receptor ligand

Transferrin receptor ligands

Transient receptor potential channel ligands

Transport mechanism, receptor/ligand

Transport mechanism, receptor/ligand binding

Twin drugs receptor ligands

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