Thyrotropin releasing hormone

Thyrotropin-releasing hormone (TRH) is a hypothalamic tripeptide (pGlu-His-Pro-NH2) that increases thyrotropin-stimulating hormone, leading 

To maintain the spatial orientation of the pharmacophore elements while not extending beyond the geometric boundaries of THR itself, researchers at Hoffmann-La Roche selected the 1,3,5-ds-trisubstituted cyclohexane framework to replace the peptide backbone. This structure was then substituted with the appropriate recognition features to yield Ro 24-9975 (87). Superposition of 

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ITiYROID AND ANTITTiYROID PREPARATIONS] (Vol 24) Thyrotropin-releasing hormone... 

Thyrotropin-releasing factor (TRF) = thyrotropin-releasing hormone (TRH) = thyroliberin. 

The BZ stmcture also has provided a molecular scaffold for a number of peptide receptor ligands (26). Antagonists for the cholecystokinin (CCK-A) receptor, eg, devazepide (65), the thyrotropin-releasing hormone (TRH) receptor, eg, midazolam (66), and the /i -opiate receptor, eg, tifluadom (67), as well as a series of ras famyl transferase inhibitors, eg, BZA-2B (68) (30) have been identified (Table 4). 

DUP996 [105431-72-9] nicotine [54-11-5] antigalanin agents somatostatin [51110-01-0] thyrotropin-releasing hormone [24305-27-9]... 

Prolactin is an essential hormone for normal production of breast milk following childbirth. It also plays a pivotal role in a variety of reproductive functions. Prolactin is regulated primarily by the hypothalamus-pituitary axis and secreted solely by the lactotroph cells of the anterior pituitary gland. Under normal conditions, secretion of prolactin is predominantly under inhibitory control by dopamine and acts on the D2 receptors located on the lactotroph cells. Increase of hypothalamic thyrotropin-releasing hormone (TRH) in primary hypothyroidism can stimulate the release of prolactin. 

Located in close proximity to the primary capillary plexus in the hypothalamus are specialized neurosecretory cells. In fact, the axons of these cells terminate on the capillaries. The neurosecretory cells synthesize two types of hormones releasing hormones and inhibiting hormones (see Table 10.2). Each of these hormones helps to regulate the release of a particular hormone from the adenohypophysis. For example, thyrotropin-releasing hormone produced by the neurosecretory cells of the hypothalamus stimulates secretion of thyrotropin from the thyrotrope cells of the adenohypophysis. The hypo-thalamic-releasing hormone is picked up by the primary capillary plexus travels through the hypothalamic-hypophyseal portal veins to the anterior pituitary leaves the blood by way of the secondary capillary plexus and exerts its effect on the appropriate cells of the adenohypophysis. The hypophyseal hormone, in this case, thyrotropin, is then picked up by the secondary capillary plexus, removed from the pituitary by the venous blood, and delivered to its target tissue. 

Heuer H., Schafer M., ODonnell D., Walker P., Bauer K. (2000). Expression of thyrotropin-releasing hormone receptor 2 (TRH-R2) in the central nervous system of rats. J. Comp. Neurol 428, 319-26. 

Thyroliberin (thyrotropin-releasing hormone, Endomorphin 1 Methionine (MET)-enkephalin Cholecystokinin-8S (CCK-8S)... 

Werner, U., T. Kissel, and W. Stuber. Effects of peptide structure on transport properties of seven thyrotropin releasing hormone (TRH) analogues in a human intestinal cell line (Caco-2), Pharm. Res. 1997, 14, 246-250... 

Moss, J., Bundgaard, FI., Prodrugs of peptides 8. In vitro study of intestinal metabolism and penetration of thyrotropin-releasing hormone (TRH) and its prodrugs, Int. J. Pharm. 1990, 66, 39-45. 

Bacha, P., Murphy, J.R., and Reichlin, S. (1983) Thyrotropin-releasing hormone-diphtheria toxin-related polypeptide conjugates./. Biol. Chem. 258, 1565. 

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