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Epidermal growth factor receptor ligand binding

Elleman, T. C., Domagala, T., McKern, N. M., Nerrie, M., Lonnqvist, B., Adams, T. E., Lewis, J., Lovrecz, G. O., Hoyne, P. A., and Richards, K. M. et al. (2001). Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain. Biochemistry 40, 8930-8939. [Pg.23]

Trastuzumab is a recombinant DNA-derived, humanized monoclonal antibody that binds to the extracellular domain of the human epidermal growth factor receptor HER-2/ . This antibody blocks the natural ligand from binding and down-regulates the receptor. Trastuzumab is approved for the treatment of metastatic breast cancer in patients whose tumors overexpress HER-2/ . As a single agent it induces remission in about 15-20% of patients in combination with chemotherapy, it increases response rate and duration as well as 1-year survival. Trastuzumab is under investigation for other tumors that express HER-2... [Pg.1197]

See other pages where Epidermal growth factor receptor ligand binding is mentioned: [Pg.565]    [Pg.1010]    [Pg.1254]    [Pg.240]    [Pg.6]    [Pg.179]    [Pg.530]    [Pg.531]    [Pg.646]    [Pg.285]    [Pg.195]    [Pg.609]    [Pg.86]    [Pg.168]    [Pg.175]    [Pg.283]    [Pg.18]    [Pg.194]    [Pg.61]    [Pg.353]    [Pg.52]    [Pg.93]    [Pg.75]    [Pg.188]    [Pg.569]    [Pg.565]    [Pg.1010]    [Pg.1254]    [Pg.2086]    [Pg.549]    [Pg.163]    [Pg.174]    [Pg.12]    [Pg.666]    [Pg.2317]    [Pg.169]    [Pg.120]    [Pg.56]    [Pg.884]    [Pg.74]    [Pg.284]    [Pg.342]    [Pg.186]    [Pg.117]    [Pg.598]    [Pg.382]    [Pg.53]   
See also in sourсe #XX -- [ Pg.16 ]

See also in sourсe #XX -- [ Pg.16 ]



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Epidermal

Epidermal growth factor

Epidermal growth factor , receptor

Growth factors receptors

Growth receptor

Ligands receptor/ligand binding

Receptor binding

Receptor ligands

Receptor-ligand binding

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