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Receptor activator of NF-kB ligand

In addition to TLR-7 (and TLR-9), it has been reported recendy that CLL cells also express other functional toll-like receptors, such as TLR-1, TLR-2, TLR-6, TLR-10, and the closely related NODI and NOD2. The engagement of these receptors with their specific ligands leads to activation of NF-kB, enhanced survival and decreased apoptosis (Muzio et al. 2008). It is therefore possible that these... [Pg.173]

Fig. 4.4 Involvement of Fas and NMDA receptors in apoptotic and necrotic cell death. Fas ligand (FasL) Fas receptor (Fas-R) IV-methyl-D-aspartate receptor (NMDA-R) phosphatidylcholine (PtdCho) cytosolic phospholipase A2 (CPLA2) arachidonic add (ARA) arginine (Arg) nitric oxide synthase (NOS) nitric oxide (NO) superoxide (O2) peroxynitrite (ONOO ) arachidonic add (ARA) lyso-phosphatidylcholine (lyso-PtdCho) platelet-activating factor (PAF) cytochrome c (Cytc) apoptosome complex with apoptosis-activating factor-1 (Apaf-1) and poly(ADP)ribose polymerase (PARP) secretory phospholipase (SPLA2) inducible nitric oxide synthase (iNOS) cyclooxygenase-2 (COX-2) matrix metalloproteinase (MMP) nuclear factor-kappa B (NF-kB) inhibitory form of nuclear factor kappa B (I-kB/NF-kB) nuclear factor xB-response element (NF-kB-RE) inhibitory subunit of NF-kB (I-kB) tumor necrosis factor-a (TNF-a) interleukin-ip (IL-ip) and interleukin-6 (IL-6)... Fig. 4.4 Involvement of Fas and NMDA receptors in apoptotic and necrotic cell death. Fas ligand (FasL) Fas receptor (Fas-R) IV-methyl-D-aspartate receptor (NMDA-R) phosphatidylcholine (PtdCho) cytosolic phospholipase A2 (CPLA2) arachidonic add (ARA) arginine (Arg) nitric oxide synthase (NOS) nitric oxide (NO) superoxide (O2) peroxynitrite (ONOO ) arachidonic add (ARA) lyso-phosphatidylcholine (lyso-PtdCho) platelet-activating factor (PAF) cytochrome c (Cytc) apoptosome complex with apoptosis-activating factor-1 (Apaf-1) and poly(ADP)ribose polymerase (PARP) secretory phospholipase (SPLA2) inducible nitric oxide synthase (iNOS) cyclooxygenase-2 (COX-2) matrix metalloproteinase (MMP) nuclear factor-kappa B (NF-kB) inhibitory form of nuclear factor kappa B (I-kB/NF-kB) nuclear factor xB-response element (NF-kB-RE) inhibitory subunit of NF-kB (I-kB) tumor necrosis factor-a (TNF-a) interleukin-ip (IL-ip) and interleukin-6 (IL-6)...
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Activation of receptors

Active Ligands

Active receptor

KB activities

Ligand activated

Receptor activation

Receptor activator of NF-kB

Receptor activity

Receptor ligands

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