Opioid receptors ligand binding model

OPIOID RECEPTORS AND LIGAND/RECEPTOR BINDING MODELS... 

Studies with the irreversible mu antagonist beta-FNA provided a linkage between the in vitro ligand binding evidence for a mu-delta opioid receptor complex and the in vivo evidence described above [18]. As noted above, in vivo administration of beta-FNA blocks delta agonist modulation in the antinociception models and delta antagonist effects in the seizure, endotoxic shock, and striatal cAMP models. As reported by Rothman et al. [18], either pretreating membranes with beta-FNA or ICV administration of... 

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