Nuclear receptor Ligand binding domain

Gronemeyer, H. (2000) Nuclear receptor ligand-binding domains three-dimensional structures, molecular interactions and pharmacological implications. Trends in Pharmacological Sciences, 21, 381-388. 

Simons SS Jr. Structure and function of the steroid and nuclear receptor ligand-binding domain. In The Molecular Biology of Steroid and Nuclear Hormone Receptors. Freedman LP, ed. 1998. Birkhauser, Boston, pp. 35-104. 

Moras D, Gronemeyer H. 1998. The nuclear receptor ligand-binding domain ... 

Folkertsma, S., van Noort, P., Van Durme, J., Joosten, H.J., Bettler, E., Fleuren, W., Oliveira, L., Horn, F., de Vlieg, J. and Vriend, G. (2004) A family-based approach reveals the function of residues in the nuclear receptor ligand-binding domain. Journal of Molecular Biology, 341, 321-335. 

Moras, D. and Gronemeyer, H. (1998) The nuclear receptor ligand-binding domain structure and function. Current Opinion in Cell Biology, 10, 384-391. 

Nuclear Hormone Receptors Ligand Binding Domains... 

Tab. 1.1 PDB codes of all nuclear hormone receptor-ligand-binding domains in the protein data bank as of December 2002.

Dubbink, H.J., Hersmus, R., Pike, A.C.W., Molier, M., Brinkmann, A.O., Jenster, G. and Trapman, J. (2006) Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping. Molecular Endocrinology, 20, 1742-1755. 

The use of structure-based virtual screening toward novel nuclear hormone receptor antagonists was described by Schapira et al. [263]. As only X-ray structures of ligand binding domains of agonist-bound nuclear receptors with exception of the antagonist-bound estrogen receptor-a are available, the authors constructed an inactive ... 

A typical nuclear receptor contains a domain responsible for the DNA binding (domain C), the ligand binding and dimerization (E), and for the transactivation and other protein-protein interactions (A,B,E,F). Furthermore, there are also nuclear localization signals (D). 

Bouruet, W., Ruff, M., Chambon, P. Gronemeyer, H. and Moras, D Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-a (1995) Nature 375, 377-382... 

Uppenberg, J., Svensson, C., Jaki, M., Bertilsson, G., Jendeberg, L., and Berken-stam, A. (1998). Crystal Structure of the Ligand Binding Domain of the Human Nuclear Receptor PPARy./ Biol. Chem. 273, 31108-31112. 

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