Receptor ligand gated ion channel

HT3 receptors belong to the ligand-gated ion channel receptor superfamily, similar to the nicotinic acetylcholine or GABAa receptors and share elec-trophysiological and structural patterns. The receptors... 

The simplest agonist mechanism that can be used to describe activation of the ligand-gated ion-channel receptors is that first suggested by del Castillo and Katz (1957) for activation of nAChRs at the neuromuscular junction ... 

A simple mechanism for competitive antagonism of a ligand-gated ion-channel receptor would be as follows ... 

Figure 2.5. The synapse. GPCR = guanine nucleotide-binding protein-coupled receptor, LGICR = ligand-gated ion channel receptor, SB = synaptic bouton, T = neurotransmitter, YOC = voltage-operated ion channel protein, YOCC = voltage-operated calcium channel protein, Ast = astrocyte, AA = axoaxonal synapse, ASD = axosomatic or axodendritic synapse. GPCR 1 = receptor protein, 2 = G-protein, 3 = enzyme, 4 = ion channel protein.

GABAa receptors are chloride channels and members of a superfamily of ligand-gated ion channel receptors 293 A family of pentameric GABAA-receptor protein subtypes exists 294 The GABAa receptor is the major molecular target for the action of many drugs in the brain 296... 

Neuro steroids, which may be physiological modulators of brain activity, enhance GABAa receptor function 297 The three-dimensional structures of ligand-gated ion channel receptors are being modeled successfully 297 Mouse genetics reveal important functions for GABAa receptor subtypes 297... 

GABAa receptors are chloride channels and members of a superfamily of ligand-gated ion channel receptors. 

Figure 2.8 A ligand-gated ion channel receptor. ACh = acetylcholine. The binding of ACh to the a subunits opens the ion channel, allowing Na ions to flow through the channel into the cell.

For ligand-gated ion channel receptor expression studies, stage V and VI oocytes are preferred (see earlier). Under a dissecting microscope, oocytes of this stage that are in good condition are sorted from the rest and then incubated at 16-18°C in MBM overnight. Incubation in hypertonic phosphate... 

Binding Thermodynamics of Ligand-Gated Ion Channel Receptors... 

Table 2.5 Thermodynamic parameters, AG°, AH0 and AS° of a series of typical ligands to six ligand-gated ion channel receptors so far studied...

Heritable Mutations in the Glycine, GABAa, and Nicotinic Acetylcholine Receptors Provide New Insights into the Ligand-Gated Ion Channel Receptor Superfamily... 

Van Hooft JA, Vijverbcrg HP. Phosphorylation controls conductance of 5-HT3 receptor ligand-gated ion channels. Receptors Channels 1995 3(1) 7—12. 

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