Receptor Mutation and Ligand Modification

The combination of receptor mutagenesis and ligand modification helps to elucidate specific interactions between residues of the ligand and residues within the receptor sequence. 

Examples for fhe identification of G-protein-coupled receptor binding sites by photoaffinity labeling are the renal V2 vasopressin receptor [99] and the human brain cholecystokininB receptor [97]. 

4 Smit, M.J., Leurs, R., Alewijnse, A.E., Blauw, j.. Van Nieuw Amerongen, 

11 Arvanitakis, L, Geras-Raaka, E. and Gershengorn, M.C., Trends Endocrinol. Metabol., 1998, 9, 27-31. 

25 Gujer, R., Aldecoa, a., Buehlmann, N., Leuthaeuser, K., Muff, R., Fischer, 

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