Ionotropic glutamate receptors ligand binding

Arinaminpathy, Y Sansom, M. S. P, and Biggin, B. C. (2002) Molecular Dynamics simulations of the ligand binding domain of the ionotropic glutamate receptor GluR2. Biophys. J. 82,676-693. 

McFeeters, R. L., and Oswald, R. E. (2002). Structural mobility of the extracellular ligand-binding core of an ionotropic glutamate receptor. Analysis of NMR relaxation dynamics. Biochem. 41, 10472-10481. 

Pentikainen U, Settimo L, Johnson MS et al (2006) Subtype selectivity and flexibility of ionotropic glutamate receptors upon antagonist ligand binding. Org Biomol Chem 4 1058-1070... 

Fig. 3. Architecture of ionotropic glutamate receptors. A single subunit is formed by three transmembrane domains, a membrane-reentering loop and an extended amino terminal domain (ATD). The N-terminal portion of ATD is homologous to LIVBP. The C-terminal portion of ATD and the S2 segment of the extracellular loop are homologous to LAOBP and constimte the ligand-binding domain.

R 512 R, L. McFeeters and R. E. Oswald, Emerging Structural Explanations of Ionotropic Glutamate Receptor Function , FASEB J., 2004,18,428 R 513 B. Meyer and T. Peters, NMR Spectroscopy Techniques for Screening and Identifying Ligand Binding to Protein Receptors , Angew. Chem. Int. Ed., 2003,42, 864... 

---