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Receptor activator of nuclear factor-kB ligand

Kearns AE, Khosla S, Kostenuik PJ Receptor activator of nuclear factor kb ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev 2008 29 155. [PMID 18057140]... [Pg.978]

Politou M, Meletis J, et al. Soluble receptor activator of nuclear factor kB ligand-osteoprotegerin ratio predicts survival in multiple myeloma proposal for a novel prognostic index. Blood 2003 102 1064-9. [Pg.1963]

RANKL receptor activator of nuclear factor kB ligand... [Pg.1666]

Recently, two products of the osteoblast have been identified that appear to be the final common pathway in coordinating osteoblast and osteoclast activity. The first, receptor activator of nuclear factor-KB (RANK) ligand, binds to a receptor on osteoclast progenitor cells and increases osteoclast differentiation and activity. The second, osteo-protegerin (OPG), serves as a decoy receptor for RANK ligand. When OPG binds to RANK ligand, the osteoclast-stimulation activity is prevented. The relative ratios of these two molecules determine bone turnover. [Pg.1892]

These receptors mediate the effects of TNFa (TNF receptors), and of the RANK ligand, RANK-L or receptor activator of nuclear factor-kB, and its endogenous antagonist, osteoprotegerin (OPG), RANK receptors. [Pg.98]

Fig. 4.4 Involvement of Fas and NMDA receptors in apoptotic and necrotic cell death. Fas ligand (FasL) Fas receptor (Fas-R) IV-methyl-D-aspartate receptor (NMDA-R) phosphatidylcholine (PtdCho) cytosolic phospholipase A2 (CPLA2) arachidonic add (ARA) arginine (Arg) nitric oxide synthase (NOS) nitric oxide (NO) superoxide (O2) peroxynitrite (ONOO ) arachidonic add (ARA) lyso-phosphatidylcholine (lyso-PtdCho) platelet-activating factor (PAF) cytochrome c (Cytc) apoptosome complex with apoptosis-activating factor-1 (Apaf-1) and poly(ADP)ribose polymerase (PARP) secretory phospholipase (SPLA2) inducible nitric oxide synthase (iNOS) cyclooxygenase-2 (COX-2) matrix metalloproteinase (MMP) nuclear factor-kappa B (NF-kB) inhibitory form of nuclear factor kappa B (I-kB/NF-kB) nuclear factor xB-response element (NF-kB-RE) inhibitory subunit of NF-kB (I-kB) tumor necrosis factor-a (TNF-a) interleukin-ip (IL-ip) and interleukin-6 (IL-6)... Fig. 4.4 Involvement of Fas and NMDA receptors in apoptotic and necrotic cell death. Fas ligand (FasL) Fas receptor (Fas-R) IV-methyl-D-aspartate receptor (NMDA-R) phosphatidylcholine (PtdCho) cytosolic phospholipase A2 (CPLA2) arachidonic add (ARA) arginine (Arg) nitric oxide synthase (NOS) nitric oxide (NO) superoxide (O2) peroxynitrite (ONOO ) arachidonic add (ARA) lyso-phosphatidylcholine (lyso-PtdCho) platelet-activating factor (PAF) cytochrome c (Cytc) apoptosome complex with apoptosis-activating factor-1 (Apaf-1) and poly(ADP)ribose polymerase (PARP) secretory phospholipase (SPLA2) inducible nitric oxide synthase (iNOS) cyclooxygenase-2 (COX-2) matrix metalloproteinase (MMP) nuclear factor-kappa B (NF-kB) inhibitory form of nuclear factor kappa B (I-kB/NF-kB) nuclear factor xB-response element (NF-kB-RE) inhibitory subunit of NF-kB (I-kB) tumor necrosis factor-a (TNF-a) interleukin-ip (IL-ip) and interleukin-6 (IL-6)...
Fig. 1 Localization of TLRs in immune cells, their ligands and a representation of TLR signaling pathways. Nucleic acid-recognizing TLRs 3, 7, 8, and 9 are located in the endolysosomes. Signaling by these receptors upon activation by their respective ligands leads to the activation and nuclear translocation of transcription factors such as the IRFs, NF-kB, and API, which promote expression of cytokines... Fig. 1 Localization of TLRs in immune cells, their ligands and a representation of TLR signaling pathways. Nucleic acid-recognizing TLRs 3, 7, 8, and 9 are located in the endolysosomes. Signaling by these receptors upon activation by their respective ligands leads to the activation and nuclear translocation of transcription factors such as the IRFs, NF-kB, and API, which promote expression of cytokines...
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See also in sourсe #XX -- [ Pg.1892 ]



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Activation of factor

Activation of receptors

Active Ligands

Active factors

Active receptor

Activity factor

Activity nuclear

KB activities

Ligand activated

Ligand-activated nuclear receptor

Ligands of Nuclear Receptors

Nuclear activation

Nuclear factor

Nuclear factor-KB

Nuclear receptor Ligands

Nuclear receptors

Receptor activation

Receptor activator of nuclear factor

Receptor activity

Receptor ligands

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