Ligand-receptor chemistry

Leprosy, chemotherapy, 20 (1983) 1 Ligand-receptor binding, 23 (1986) 41 Linear free energy, 10 (1974) 205 Literature of medicinal chemistry, 6 (1969) 66... 

Fuentes, J.A. (2005) Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(lA)R agonists with selectivity over alphal-adrenoceptors. Journal of Medicinal Chemistry, 48, 2548-2558. 

Leprosy, chemotherapy, 20 (1983) 1 Ligand-receptor binding, 23 (1986) 41 Linear free energy, 10 (1974) 205 5-Lipoxygenase inhibitors and their antiinflammatory activities, 29 (1992) 1 Literature of medicinal chemistry, 6 (1969) 66 Lithium, medicinal use of, 11 (1975) 193 Local anaesthetics, 3 (1963) 332 Lonidamine and related compounds, 21 (1984)111... 

Quantitative analysis of ligand-receptor interaction, in Comprehensive Medicinal Chemistry, vol. Hi ... 

Smith, R.G. and Sestili, J. 1980. Methods for ligand-receptor assays in clinical chemistry. Clin. Chem. 26, 543-550. 

Lipid Domains, Chemistry of Receptor Tyrosine Kinases Receptor-Ligand Interactions Receptors, Chemistry of Signal Transduction Across Membranes Virus-Based Drug Delivery... 

Agonists - The existence of two receptor populations for histamine raises the interesting question of whether the chemical mechanism of histamine interaction differs between the two receptor types. Some indications of the chemical properties which may differentiate receptor action come from studies of histamine chemistry and from structure-activity considerations of congeners. Histamine in aqueous solution is a mixture of equilibrating species, viz. ionic forms, tautomers and conformers nmr studies confirm earlier pK work indicating a N -H N -H (structures 1 and 2) tautomer ratio of approximately 4 1 for histamine monocation, and a comparable ratio for histamine base. The latter result contrasts with crystal structure data and molecular orbital predictions, and may indicate an influence of solvent on tautomer stability. Recent studies of properties pertinent to consideration of ligand-receptor interactions are conformation (MO calculations and infra-red comparison of solid state and chloroform solutions of histamine base ), electronic charge distribution, metal complexation, and phospholipid inter-... 

Motiejunas, D., Wade, R. C. Structural, energetic, and dynamic aspects of ligand-receptor interactions. In Comprehensive Medicinal Chemistry (Taylor, J. B., Triggle, D. J., Eds), Vol. 4. Elsevier, 2007, pp. 193-213. 

---