Endocrine functions

CJ-Receptors are localized ia the brain stem and limbic stmcture, regions associated with endocrine function (76). In the periphery, CJ-receptors are found in the Hver, heart, ileum, vas deferens, and on lymphocytes and thymocytes. Although there is insufficient evidence to clearly define the functional role of CNS CJ-sites, based on the effects of PCP and the interaction of haloperidol with CJ-sites, CJ-receptor ligands may be antipsychotics or used for the treatment of substance abuse. Several CJ-receptor ligands have shown neuroprotective effects in vivo. Ifenprodil (315) and CNS 1102 (316) are being developed for treatment of stroke (Table 18). 

An endocrine disrupter is an exogenous substance that causes adverse health ejfects in an intact organism, or its progeny, subseguent to changes in endocrine function. ... 

In general, the sterols perform a structural function, for example as components of the lipid layers of membranes. The Cis, C19 and C21 steroids mainly perform an endocrine function. In other words they are hormones. The bile salts (C24-steroids) fulfil a functional role in digestion in animals. 

Houten SM, Watanabe M, Auwerx J (2006) Endocrine functions of bile acids. EMBO J 25 1419-1425... 

The great diversity and amounts of hormones and regulatory molecules secreted by the GIT influence local and systemic functions. As a consequence, phytochemicals that modulate the endocrine functions of the GIT can alter its characteristics and those of other organ systems. 

The pancreas is a gland in the abdomen lying in the curvature of the stomach as it empties into the duodenum. The pancreas functions primarily as an exocrine gland, although it also has endocrine function. The exocrine cells of the pancreas are called acinar cells. They produce an alkaline fluid known as pancreatic... 

Chronic pancreatitis is an inflammatory process that occurs over a long period of time. The inflammation damages the enzyme-producing cells in the pancreas and can also disrupt or destroy the endocrine function of the pancreas by causing diffuse... 

Glucose intolerance may occur because of chronic destruction of the endocrine function of the pancreas.35... 

The pancreas is a small retroperitoneal organ located behind the stomach on the posterior abdominal wall.1,3 The pancreas has both exocrine and endocrine functions. The exact nationwide prevalence of all diseases of the pancreas has not been fully quantified however, DM, both types 1 and 2, affect nearly 21 million people in the United States alone. Some reasons for pancreas transplants include ... 

Ng TP, Goh HH, Ong HY, et al. 1991. Male endocrine functions in workers with moderate exposure to lead. BrJInd Med 48 485-491. 

Bloch E (1983). Effects of marijuana and cannabinoids on reproduction, endocrine function, development and chromosomes. In KO Fehr and H Kalant (eds), Cannabis and Health Hazards. Addiction Research Foundation, Toronto. 

Goncharova LN, Chirkov W, Rudakova LE. 1984. [Effect of the manufacture of acrylonitrile on endocrine function.] Gig Tr Prof Zabol 23-25. (Russian)... 

Most endocrine functions have already been commented on in previous chapters, so only the following will be mentioned here ... 

Moore A, Lower N (2001) The impact of two pesticides on olfactory-mediated endocrine function in mature male Atlantic salmon (Salmo salar L.) parr. Comp Biochem Physiol Part B 129 269-276... 

---