Chemokines receptor-ligand interactions

K. C. Chemokine receptor-ligand interactions measured using time-resolved fluorescence. Biochemistry 1998, 37, 2372-2377. 

The chemotaxis of mononuclear leukocytes and the migration, growth, and activation of the multiple cell types within atherosclerotic lesions are critical for the chronic inflammatory and fibroproliferative response in atherosclerosis (Ml). Chemokine-mediated attraction of leukocytes to tissues has been shown in atherosclerotic lesions (G8). Studies using knockout and transgenic murine models indicated that chemokine receptor/ligand interactions are crucial in the development of atherosclerosis (P6). Moreover, chemokines may also interfere with smooth muscle cell migration and growth, and platelet activation and other well-defined features of the atherosclerotic process (A2). 

Wu L, LaRosa G, Kassam N, et al. Interaction of chemokine receptor CCR5 with its ligands multiple domains for HIV-1 gpl20 binding and a single domain for chemokine binding. J Exp Med 1997 186(8) 1373—1381. 

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