Glucocorticoid receptor ligand-binding domain

H. E. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell 2002, no, 93-105. 

E. L., Willson, T.M., Lambert, M.H., Moore, J.T., Pearce, K.H. and Xu, H.E. (2002) Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell, 110, 93-105. 

M. Carlquist, The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain RU-486 induces a transconformation... 

Lewis, D.F.V. et al. (2002) Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor a (hERa) LBD quantitative structure-activity... 

Fig. 16.13. Steroid hormone receptors. A. Domains of the steroid hormone receptor. The transactivation domain (TAD) binds coactivators DNA-binding domain (DBD) binds to hormone response element in DNA ligand-binding domain (LBD) binds hormone NLS is the nuclear localization signal the dimerization sites are the portions of the protein involved in forming a dimer. The inhibitor binding site binds heat shock proteins and masks the nuclear localization signal. B. Transcriptional regulation by steroid hormone receptors. Additional abbreviations HSP, heat shock proteins GRE, glucocorticoid response element GIZ, glucocorticoid receptor.

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