Functions and roles

PARs are coupled to multiple G-proteins and mediate a number of well-defined cellular responses via classical second messenger and kinase pathways. PARs are differentially expressed in cells of the vasculature as well in the brain, lung, gastrointestinal tract, skin as well as other highly vascularised tissues and evidence suggests distinct physiological functions and roles in disease states [2]. 

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Review of the structure, function, and role of uncoupling proteins. 

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Holleran WM, Takagi Y, Uchida Y. Epidermal sphingoUpids metabolism, function, and roles in skin disorders. EEBS Lett. 2006 580 5456-5466. 

Nuclear Receptor Signaling Atlas. A web sited aimed at developing a comprehensive understanding of the structure, function, and role in disease of nuclear receptors. Available at http //www.nursa.org/ index, cfm. 

This chapter will give you an overview of recent approaches for drug development, focusing on the function and roles of carbohydrates. O Section 2 will outline the biochemical functions of polysaccharide (neutral polysaccharide, chitin and chitosan, glycosaminoglycan, and synthetic polysaccharides) and glycopolymers and the perspectives of their medicinal/medical use. O Section 3 will outline recent biopharmaceutical research and development, utilizing... 

Sharom FJ (2008) ABC multidrug transporters structure, function and role in chemore-sistance. Pharmacogenomics 9 105-127... 

Murphy, P. M. (1996). Chemokine receptors, structure, function and role in microbial pathogenesis. Cytokine Growth Factor Rev. 7, 47-64. 

Johnson, G. L., and Nakamura, K. (2007). The c-Jun kinase/stress-activated pathway Regulation, function and role in human disease. Biochim Biophys Acta 1773(8), 1341-1348. 

Westergard L, Christensen HM, Harris DA (2007) The cellular prion protein (PrPc) its physiological function and role in disease. Biochim Biophys Acta 1772 629-644... 

The understanding of the biological function and role of individual HDAC isoforms in the context of CNS disorders is still in its infancy, but recent work has clearly shed light on the relevance of this protein class. A number of isoform and class selective inhibitors of HDACs/sirtuins are now available, which will serve as tools... 

Hanukoglu, I. (1992). Steroidogenic enzymes Structure, function, and role in regulation of steroid hormone biosynthesis. J. Steroid. Biochem. Mol. Biol 43, 779-804. 

Norris EH, Giasson Bl, Lee VM. a-Synuclein normal function and role in neurodegenerative diseases. Curr Top Dev Biol 2004 60 17-54. 

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