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Receptor-ligand interactions, affinity

Specifically, the responses increased over a wide range of concentrations, and logit/log (Hill) plots yielded slopes of less than 0.8 (not shown). We adopted the minimal model of 1 1 stoichiometry for ligand/receptor interaction, and foresaw three possible contributory causes of shallow response curves (1) multiple receptors with graded affinities but additive effects (2) metabolic inactivation of the peptides during the course of two or three hour assays, and (3) desensitization (down-regulation) during the course of the assays. [Pg.188]

See other pages where Receptor-ligand interactions, affinity is mentioned: [Pg.49]    [Pg.49]    [Pg.39]    [Pg.219]    [Pg.133]    [Pg.152]    [Pg.56]    [Pg.190]    [Pg.342]    [Pg.214]    [Pg.163]    [Pg.181]    [Pg.264]    [Pg.64]    [Pg.209]    [Pg.18]    [Pg.109]    [Pg.109]    [Pg.13]    [Pg.128]    [Pg.129]    [Pg.130]    [Pg.422]    [Pg.45]    [Pg.131]    [Pg.61]    [Pg.202]    [Pg.208]    [Pg.97]    [Pg.99]    [Pg.8]    [Pg.11]    [Pg.216]    [Pg.1]    [Pg.204]    [Pg.433]    [Pg.111]    [Pg.63]    [Pg.11]    [Pg.156]    [Pg.71]    [Pg.75]    [Pg.108]    [Pg.422]    [Pg.144]    [Pg.295]    [Pg.473]    [Pg.496]    [Pg.14]    [Pg.59]   
See also in sourсe #XX -- [ Pg.204 ]



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Affinity interactions

Affinity ligands

Ligand interactions

Ligand-receptor interactions

Receptor affinity

Receptor interaction

Receptor ligands

Receptor-ligand interactions, affinity capillary electrophoresis

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