Receptors ancillary ligand

Fig. 8 Enhanced receptor effect on analyte binding affinity. Upon chelation, the electronegative ancillary ligand causes a polarization of the Ln + ion, inducing an increased positive charge at the binding site. This anisotropy results in an increased binding affinity for the anionic analyte. Limit of detection (LOD) values shown are for the Tb/D02A/ dipicolinate system.

By enhancing the binding affinity between anal5rte and receptor complex, the ancillary ligand confers additional stability to... 

Fig. 1. Binding of an analyte to a lanthanide-based receptor produces a luminescent ternary complex. The ancillary (receptor or helper) ligand is shown in dark gray.

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