Molecular ligand-receptor interaction

The interaction between ligands and their receptors is clearly a dynamic process. Once the static model of ligand-receptor interaction has been obtained, the stability of ligand-receptor complexes should be evaluated by means of molecular dynamics simulations [18]. 

Eukaryotic ABC transport system Phosphotransferase system (PTS) Ion-coupled transport system Signal Transduction Two-component system Bacterial chemotaxis MAPK signaling pathway Second messenger signaling pathway Ligand-Receptor Interaction G-protein-coupled receptors Ion-channel-linked receptors Cytokine receptors Molecular Assembly Ribosome assembly Flagellar assembly Enzyme assembly... 

The histamine H3 receptor has not been cloned yet and hence, virtually nothing is known about the receptor topography. However, ligand based molecular modelling studies have contributed to the understanding of the molecular features involved in ligand-receptor interaction. 

Sklar, L. A., Vilven, J., Lynam, E., Neldon, D., Bennett, T. A., and Prossnitz, E. (2000). Solubilization and display of G protein-coupled receptors on beads for real-time fluorescence and flow cytometric analysis. Biotechniques 28, 976-980, 982-985. Sklar, L. A., Edwards, B. S., Graves, S. W., Nolan, J. P., and Prossnitz, E. R. (2002). Flow cytometric analysis of ligand-receptor interactions and molecular assemblies. Annu. Rev. Biophys. Biomol. Struct. 31, 97—119. 

The main purpose of this section has been to highlight the rapid progress over recent years in studies of ligand-receptor interactions at a molecular level, and the new opportunities that arise for peptide mimetic design. This also emphasizes the need for new approaches and molecular tools in the design of conformationally defined, small molecule peptide and protein mimetics, which is the main topic of the remaining sections in this article. 

Ligand-receptor interaction is an important initial step in protein function. The structure of ligand-receptor complex profoundly affects the specificity and efficiency of protein action. The molecular docking performs the computational prediction of... 

B. A. Luty, Z. R. Wasserman, P. Stouten, C. N. Hodge, M. Zacharias, and J. A. McCammon, J. Comput. Chem., 16,454 (1995). A Molecular Mechanics/Grid Method for Evaluation of Ligand-Receptor Interactions. 

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