Kinetics receptor/ligand binding

S. Chesla, P. Selvaraj, and C. Zhu Measuring Two-Dimensional Receptor-Ligand Binding Kinetics by Micropipette. Biophys. J. 75, 1553 (1998). 

Determine the rate of receptor-ligand binding from kinetic data. 

Kinetics of Cell Surface Receptor-Ligand Binding ... 

Kinetics Trans- formations, Corrosion Devitrification, Nucleation, Growth Polymerization, Degradation Deposition, Infiltration Receptors, Ligand binding... 

Abele, R., Keinanen, K., and Madden, D. R. (2000). Agonist-induced isomerization in a glutamate receptor ligand-binding domain. A kinetic and mutagenetic analysis. J. Biol. Chem. 275, 21355-21363. 

Bradfield CA, Kende AS, Poland A. 1988. Kinetic and equilibrium studies of Ah receptor-ligand binding use of [125I]2-iodo-7,8-dibromodibenzo-p-dioxin. Molec. Pharmacol. 34 229-37... 

CEP receptors exhibit high ligand affinity and saturation kinetics for ligand binding. The protein portion of these complexes appears to participate in ligand-receptor interaction since protease treatment of aortic CEP complexes abolishes uptake [24]. Binding is competitively inhibited by polyanions in a pattern similar to the inhibition observed for the acetyl-LDL receptor [24]. However, the CEP receptor appears to be distinct from the acetyl-LDL receptor since their ligands do not mutually compete for uptake [24]. 

For the other extreme in which receptor/ligand binding kinetics are fast compared to two-dimensional diffusion, switching of ligand among free receptors may be a major contributor to G-protein activation. At low... 

Lortat-Jacob, H., Chouin, E., Cusack, S., and van Raaij, M.J. (2001). Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions./. Biol. Chem. 276, 9009-9015. 

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