Ligand-receptor analysis

Applications. From the first successful reports on protein analysis by CE, it became obvious that the unique separation power of the method can be also applied for ligand-receptor analysis to separate bound from free analyte. This is the main prerequisite for evaluating biomolecular interaction by most of the conventional methods. 

To study the presumed additional ligand-receptor interactions mentioned earlier in more detail, a conformational analysis was performed on a subset of compounds cho-... 

GPCRs in order to serve as templates and aid in the analysis of ligand-receptor complexes. Thus, the validated structural insights described earlier show that it is not appropriate to utilize the crystal structure of the inactive form of rhodopsin as a universal template if the modeled functional details pertain to an activated (e.g., agonist-bound) state of the GPCR. 

KrishnaNR, JayalakshmiV (2008) Quantitative Analysis of STD-NMR Spectra ofReversibly Forming Ligand-Receptor Complexes. 273 15-54... 

Sklar, L. A. and Finney, D. A. (1982) Analysis of ligand-receptor interactions with the fluorescence activated cell sorter. Cytometry 3,161-165. 

Quantitative analysis of ligand-receptor interaction, in Comprehensive Medicinal Chemistry, vol. Hi ... 

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