Ligand receptor binding studies

Adjuvants such as fluoride ions, were shown to suppress the quenching effect from uric acid present in serum sample [10]. Additionally, a lanthanide complex designed for ceU-based assay should be insensitive to luminescence quenching by azide [27], which is a common internalization inhibitor used in ligand-receptor binding studies [28]. 

Hulme, E. C. and Birdsall, N. J. M., Strategy and tactics in receptor binding studies, in Receptor-Ligand Interactions A Practical Approach, Hulme, E. G, Ed., IRL Press, Oxford, 1992, chap. 4. 

Tahtaoui C, Guillier F, Klotz P, Galzi JL, Flibert M, Ilien B (2005) On the use of nonfluo-rescent dye labeled ligands in FRET-based receptor binding studies. J Med Chem 48 7847-7859... 

Recent studies have explored several GPCR targets with respect to ligand-receptor binding interactions using site-directed mutagenesis to explore agonist... 

Further studies of phenolic analogs of 4-phenylpiperidine analgesics— especially those with preferred axial 4-phenyl chair conformations—are therefore clearly important for the elucidation of the ligand-receptor binding modes of derivatives based on pethidine. 

Ligand-Receptor Modeling Studies of Endocannabinoid Binding. 263... 

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