Ligand-receptor association

Positive standard entropy of the ligand-receptor association in this experimental setup means that there is a lot more free ligand and receptor than the R L complex. 

The mechanisms of action of the NRs may be classed in an ultrasimplified way into two main categories according to the area of the cell where the initial ligand-receptor association occurs, and the subcellular distribution of NR in the absence of ligand. Small cellular substances such as natural hormones diffuse through the cell membrane and bind to the receptor localized in the cytosol... 

Kinetic experiments reveal similar ligand-receptor association and dissociation rates in both rat and mollusc preparations (Fig. 1). Scatchard analyses of binding at equilibrium show that I-labeled TxVIA binds to a single class of high affinity and low capacity sties in both Helix and rat membranes (Fig. 1C, Table I). There is a good correlation between the Kd values calculated from the kinetic rate constants of Fig. 1, A and B (3.4 nM for Helix and 2.5 nM for rat), and the values obtained directly from Scatchard analysis (Table I). Voltage... 

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