Ligand-receptor interactions analysis

To study the presumed additional ligand-receptor interactions mentioned earlier in more detail, a conformational analysis was performed on a subset of compounds cho-... 

Sklar, L. A. and Finney, D. A. (1982) Analysis of ligand-receptor interactions with the fluorescence activated cell sorter. Cytometry 3,161-165. 

Quantitative analysis of ligand-receptor interaction, in Comprehensive Medicinal Chemistry, vol. Hi ... 

Sklar, L. A., Vilven, J., Lynam, E., Neldon, D., Bennett, T. A., and Prossnitz, E. (2000). Solubilization and display of G protein-coupled receptors on beads for real-time fluorescence and flow cytometric analysis. Biotechniques 28, 976-980, 982-985. Sklar, L. A., Edwards, B. S., Graves, S. W., Nolan, J. P., and Prossnitz, E. R. (2002). Flow cytometric analysis of ligand-receptor interactions and molecular assemblies. Annu. Rev. Biophys. Biomol. Struct. 31, 97—119. 

Gounarides JS, Chen A, Shapiro MJ, Nuclear magnetic resonance chromatography applications of pulse gradient diffusion NMR to mixture analysis and ligand-receptor interactions, J. Chromatogr., B Biomed. Sci. Applic., 725 79-90, 1999. 

The absolute orientations of methyl substitution that favor or have minor influence on the ligand-receptor interactions of the reversed ester of pethidine identified by the preceding analysis are summarized in terms of the equatorial 4-phenyl chair (26), and the concordance of the stereochemical SAR of the remaining C-methyl derivatives with these deductions may now be examined. 

A critical analysis of the on and off rates of ligand-receptor interactions made it clear that deactivation of a heptahelical receptor can not be determined by the decay of the... 

Drug-receptor interactions may quantitatively differ among rapidly converting multiple receptor states that are induced by agonist binding. While most studies commonly focus on analysis of ligand-receptor interactions and cellular responses under presumed steady-state conditions, experimental techniques available for the quantitative analysis of drug-receptor interactions with transient receptor conformational... 

Some of the more likely encountered possible hmitations in thermodynamic analysis, particularly for ligand-receptor interactions, include fhe following ... 

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