Peptide receptors ligands

The BZ stmcture also has provided a molecular scaffold for a number of peptide receptor ligands (26). Antagonists for the cholecystokinin (CCK-A) receptor, eg, devazepide (65), the thyrotropin-releasing hormone (TRH) receptor, eg, midazolam (66), and the /i -opiate receptor, eg, tifluadom (67), as well as a series of ras famyl transferase inhibitors, eg, BZA-2B (68) (30) have been identified (Table 4). 

Peptide Receptor Ligands from Phage Display Peptide Library. 269... 

There has been substantial progress in the construction of phage-displayed peptide libraries and in screening methods with the libraries to isolate peptide receptor ligands [66,116-119]. Phage display peptide libraries offer opportunities to characterize peptide binding specificity of important proteins, such as... 

Tables. Selected non -peptide receptor ligands for diagnostic radiopharmaceuticals ...

Daines, R.A. (SmithKIine Beecham Corporation, USAJ Preparation of 3,4-dinitrobenzamides as calcitonin gene-related peptide receptor ligands, W09809630 (1998). 

Quehenberger O, Pan ZK, Prossnitz ER, Cavanagh SL, Cochrane CG, Ye RD. Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach. Biochem Biophys Res Commun 1997 238 377-381. 

Ruzza, P. Calderan, A. (2011) Radiolabeled peptide-receptor ligands in tumor imaging Expert Opin. Med. Diagn., Vol. 5, No. 5, pp. 411-424. 

There are now many examples of novel peptide transmitter systems that have been identified through orphan receptor ligand screening and greatly impacted the basic understanding of human physiology. Prime examples for the discovery of novel transmitter with therapeutic implications are the neuropeptides orphaninFQ/... 

While none of these neutrophil receptors has yet been sequenced, partial purification of the formyl peptide receptors has been reported (16). The formyl peptide receptor is particularly attractive because of the extensive structure-activity studies on peptide ligands by Freer and coworkers (17,18). The receptor is a trans-membrane glycoprotein with apparent molecular weight of 60,000 based on proteolysis (19) and photoaffinity (20) labeling studies. 

Recently, nonpeptide compounds have been developed for many peptide receptor systems. These compounds, which usually are discovered through screening of chemical files, generally do not resemble the corresponding peptide ligands chemically. Nevertheless, they act as specific and... 

The general types of protein-protein interactions that occur in cells include receptor-ligand, enzyme-substrate, multimeric complex formations, structural scaffolds, and chaperones. However, proteins interact with more targets than just other proteins. Protein interactions can include protein-protein or protein-peptide, protein-DNA/RNA or protein-nucleic acid, protein-glycan or protein-carbohydrate, protein-lipid or protein-membrane, and protein-small molecule or protein-ligand. It is likely that every molecule within a cell has some kind of specific interaction with a protein. 

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