Multiple receptor ligands

Busch. D.H. Ligand design for enhanced molecular organization-selectivity and specific sequencing in multiple receptor ligands, and orderly molecular entanglements. NATO ASI Ser.. Ser. C 1994, 448, 55-80. 

LIGAND DESIGN FOR ENHANCED MOLECULAR ORGANIZATION-SELECTIVITY AND SPECIFIC SEQUENCING IN MULTIPLE RECEPTOR LIGANDS, AND ORDERLY MOLECULAR ENTANGLEMENTS... 

Fig. 3.4 Three models for prospective function(s) for OBPs during perireceptor delivery of a signal molecule odourant <=> protein <=> receptor site interactions could involve multiple roles. Ligand , OBP , combination(s) buffer and/or carrier and/or transducer from Pelosi, 1994).

In this model, OBPs participate in the selective transport of pheromone and other semiochemicals to their olfactory receptors. The selectivity of the system is likely to be achieved by layers of filters [ 16], i.e., by the participation of compartmentalized OBPs and olfactory receptors. It seems that OBPs transport only a subset of compounds that reach the pore tubules. Some of these compounds may not bind to the receptors compartmentalized in the particular sensilla. The odorant receptors, on the other hand, are activated by a subset of compounds, as indicated by studies in Drosophila, showing that a single OR is activated by multiple compounds [66]. If some potential receptor ligand reaches the pore tubules but are not transported by OBPs, receptor firing is prevented because the receptors are protected by the sensillar lymph. In other words, even if neither OBPs nor odorant receptors (ORs) are extremely specific, the detectors (olfactory system) can show remarkable selectivity if they function in a two-step filter. 

Polk, P. (1988) Electrophysiology of benzodazepine receptor ligands multiple mechanisms and sites of action. Prog Neurobiol 31 349— 423. 

The chemotaxis of mononuclear leukocytes and the migration, growth, and activation of the multiple cell types within atherosclerotic lesions are critical for the chronic inflammatory and fibroproliferative response in atherosclerosis (Ml). Chemokine-mediated attraction of leukocytes to tissues has been shown in atherosclerotic lesions (G8). Studies using knockout and transgenic murine models indicated that chemokine receptor/ligand interactions are crucial in the development of atherosclerosis (P6). Moreover, chemokines may also interfere with smooth muscle cell migration and growth, and platelet activation and other well-defined features of the atherosclerotic process (A2). 

GH Pendew Purdue University Use tissue and cell cultures to examine the multiple mechanisms of Ah receptor regulation and seeks to determine the biochemical events from initial synthesis and assembly to translocation into the nucleus. Dr. Perdew is also examining the biochemical properties of the Ah receptor-ligand complex that affect its overall regulation. 

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