Glucocorticoid receptor ligands

Hormones and vitamins also play a role in regulation of ASBT. Both glucocorticoid receptor ligands and co-expression of the glucocorticoid receptor gene increased activity of ASBT, while there is also evidence that dihydroxy vitamin D binds directly to the vitamin D response element and increases expression of ASBT, leading to increased transport of bile acids into the enterocyte. ... 

Rosen J, Miner NJ. The search for safer glucocorticoid receptor ligands. Endocrine Rev 2005 26(3) 452-64. 

H. E. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell 2002, no, 93-105. 

Cole TJ. Glucocorticoid action and die development of selective glucocorticoid receptor ligands. Biotechnol. Annu. Rev. 2006 12 269-300. 

Miner, J.N., Hong, M.H. and Negro-Vilar, A. (2005) New and improved glucocorticoid receptor ligands. Expert Opinion on Investigational Drugs, 14, 1527-1545. 

E. L., Willson, T.M., Lambert, M.H., Moore, J.T., Pearce, K.H. and Xu, H.E. (2002) Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell, 110, 93-105. 

M. Carlquist, The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain RU-486 induces a transconformation... 

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