Acetylcholine receptor ligands

Turchi J, Holley LA, Sarter M. (1995). Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats. Psychopharmacology (Berlin). 118(2) 195-205. 

Milbiun T, Matsubara N, BrUrngton AP et al (1989) Synthesis, photochemistry, and biological activity of a caged photolabile acetylcholine receptor ligand. Biochemistry 28 49-55... 

Briggs CA, Anderson DJ, Brioni JD, Buccafusco JJ, Buckley MJ, et al. 1996. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav 57 231-241. 

Breining, S.R. 2004. Recent developments in the synthesis of nicotinic acetylcholine receptor ligands. Curr Top Med Chem 4, 609-629. 

Novel 2-(2 -furo[3,2-6]pyridinylpyrrolidines potent neuronal nicotinic acetylcholine receptor ligands. Bioorg. Med. Chem. Lett. 7,... 

Lin, N.-H., Carrera, G.M., Anderson, D.J., 1994. Synthesis and evaluation of nicotine analogs as neuronal nicotinic acetylcholine receptor ligands. J. Med. Chem. 37, 3542-3553. 

D.L., Decker, M.W., Brioni, J.D., Buckley, M.J., Rodrigues, A.D., Marsh, K.G., Anderson, D.J., Buccafusco, J.J., Prendergast, M.A., Sullivan, J.P., Williams, M., Americ, S.P., Holladay, M.W., 1997. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmeth-oxy)pyridine (ABT-089) an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. J. Med. Chem. 40, 385-390. 

Schmitt, J.D., Sharpies, C.G.V., Caldwell, W.S., 1998. Aromatic-cation interactions in nicotinic acetylcholine receptor ligand binding. In Book of Abstracts, 216th ACS National Meeting, Boston. American Chemical Society, Washington, DC, MEDI-153. 

Walker, J. W., McCray, J. A. Hess, G. P. (1986). Photolabile protecting groups for an acetylcholine receptor ligand. Synthesis and photochemistry of a new class of o-nitrobenzyl derivatives and their effects on receptor function. Biochemistry, 25, 1799-805. 

Hydrophilicity analysis of lapemis toxin showed that the central loop is the most hydrophilic region. Since the ligand-binding region of the acetylcholine receptor is in the outside of the cell membranes, it is also hydrophilic. Therefore, it is also logical that the most hydrophilic portion of neurotoxin binds to the acetylcholine receptor-ligand-binding site, which is also hydrophilic. 

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