Receptor ligand gated

There are two main types of ion channel receptors ligand-gated and voltagegated. In addition, some ion channels are regulated through GPCRs or via activation by amino acids. 

Ito Y, Segawa K, Fukuda H. (1995). Functional diversity of GABAA receptor ligand-gated chloride channels in rat synaptoneurosomes. Synapse. 19(3) 188-96. 

Key Words Serotonin3 receptor 5-hydroxytryptamine3 receptor Cys-loop receptor ligand-gated ion channel ionotropic receptor neurotransmitter binding site. 

Van Hooft JA, Vijverbcrg HP. Phosphorylation controls conductance of 5-HT3 receptor ligand-gated ion channels. Receptors Channels 1995 3(1) 7—12. 

Figure 19.2. Schematic representation of some receptor superfamilies. This figure represents the common mechanisms of the four major receptor families discussed in Section 19.2. Example 1 is of the G protein-coupled receptor. Example 2 represents the ionotropic receptor (ligand-gated ion channel) superfamily, on which multiple binding sites are known to exist (see Figure 19.1). Example 3 represents the steroid receptor superfamily. Example 4 depicts the enzyme-linked receptor superfamily.

For any chemical messenger to elicit an effect it must first be recognised by the cell. Peptide messengers interact with cell-surface receptors (peptides do not cross the membrane), whereas steroid- and lipid-derived messengers diffuse across the cell membrane and interact with intracellular receptors. Ligand-gated ion-channel receptors are a class of receptor that may occur either at the cell surface or within the cell. 

HT receptors consist of at least 3 distinct types of molecular structures G protein-couples receptors, ligand-gated ion channels and transporters (Table 1) [62],... 

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