Serotonergic receptor ligand

Wald J, Alberto R, Ortner K, Candreia L (2001) Aqueous one-pot synthesis of derivatized cyclopentadienyl-tricarbonyl complexes of 99mTc with an in situ CO source application to a serotonergic receptor ligand. Angew Chem Int Ed Engl 40 3061-3066... 

Scheme 14 Labelling of a serotonergic receptor ligand from the aryl-piperazine type, derivatized with a Schiff-base type bidentate chelator...

Wald J, Alberto R, Ortner K, Candreia L (2001) Aqueous one-pot synthesis of derivatized cyclo-pentadienyl-tricarbonyl complexes of Tc-99m with an in situ CO source application to a serotonergic receptor ligand. Angew Chem Int Edit 40 3062-3066 Wei LFi, Babich J, Zubieta J (2005) Bifunctional chelates with mixed aromatic and aliphatic amine donors for labeling of biomolecules with the [Tc(CO)3] and [Re(CO)3] -cores. Inorg Chim Acta 358 3691-3700... 

If presynaptic histamine receptors are more uniform than presynaptic dopamine receptors, the contrary holds true for presynaptic serotonin receptors they are even more diverse than presynaptic dopamine receptors. As mentioned in the Introduction, presynaptic 5-HT3 receptors, being ligand-gated ion channels, are covered in the chapter by Dorostkar and Boehm and will be mentioned here only occasionally. Presynaptic G protein-coupled 5-HT receptors inhibit the release of serotonin from serotonergic axon terminals and inhibit or enhance the release of other neurotransmitters (Table 4). 

Beene DL, Brandt GS, Zhong W, Zacharias NM, Lester HA, Dougherty DA. Cation-pi interactions in ligand recognition by serotonergic (5-HT(3A)) and nicotinic acetylcholine receptors the anomalous binding properties of nicotine. Biochemistry 2002 41(32) 10,262-10,269. 

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