Nuclear receptor Ligands

Figure 16.3 Nuclear receptor ligands from virtual screening.

Gronemeyer, H. (2000) Nuclear receptor ligand-binding domains three-dimensional structures, molecular interactions and pharmacological implications. Trends in Pharmacological Sciences, 21, 381-388. 

Nuclear Receptor Ligands Bearing C2B10 Cages... 

J.A., and Wilson, T.M. Selection, application, and validation of a set of molecular descriptors for nuclear receptor ligands. Book of Abstracts,... 

Although prostanoids can activate peroxisome proliferator-activated receptors (PPARs) if added in sufficient concentration in vitro, it remains questionable whether these compounds attain concentrations sufficient to function as endogenous nuclear-receptor ligands in vivo. 

Parker, G.J. et al. 2000. Development of high-throughput screening assays using fluorescence polarization nuclear receptor-ligand-binding and kinase/phosphatase assays. J. Biomol. Screen. 5, 77-88. 

Kagechika et al. reported the preparation of a retinoic nuclear receptor ligand utilizing the BINAP/Pd-catalyzed C-N bond forming reaction [103]. The aniline derivative below was coupled with 4-iodoethylbenzoate in 48% yield, Eq.(lOl). 

Chini, M. G. Jones, C. R. ZampeUa, A. D Auria, M. V. Renga, B. Fiorucci, S. Butts, C. P Bifulco, G. Quantitative NMR-derived interproton distances combined with quantum mechanical calculations of chemical shifts in the stmeochemical determination of conicasterol F, a nuclear receptor ligand from theonella swinhoei, ... 

R V. Weatherman, R J. Fletterick, and T. S. Scanlan. Nuclear receptor ligands and ligand binding domain. Atom Rev Biochem, 68, 576, 1999. 

A New Medicinal Application of Boron Clusters. Potent Nuclear Receptor Ligands Bearing Carborane as a Hydrophobic Pharmacophore... 

Weatherman RV, Fletterick RJ, Scanlan TS. Nuclear-receptor ligands and ligand-binding domains. Annu. Rev. Biochem. 1999 68 559-581. 

Simons SS Jr. Structure and function of the steroid and nuclear receptor ligand-binding domain. In The Molecular Biology of Steroid and Nuclear Hormone Receptors. Freedman LP, ed. 1998. Birkhauser, Boston, pp. 35-104. 

Moras D, Gronemeyer H. 1998. The nuclear receptor ligand-binding domain ... 

NUCLEAR RECEPTOR LIGANDS WITH A 3,3-DIPHENYLPENTANE SKELETON... 

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