Cell cycle protein modulation ligand receptor binding

This concept is illustrated schematically in Fig. 1.3 [20]. This diagram summarizes the discovery of new modulators of both cell cycle progression and viral entry. The crux of the whole concept is the observation that Nature pairs nonpeptide small molecules with relevant protein receptors, and the number of binding-site topologies for small molecule ligands across aU protein families is limited. Phenotypic screening of the library of enantiopure a,p-unsaturated-8-lactones was exceptionally successful and has identified potent modulators of the two unrelated biological processes. In one case, the compounds are inhibitors of cell... 

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