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Kinase activities

This method has been successfully applied to the substituted indole 2.6B, an analogue of the teleocidin type of protein kinase activators[ll]. [Pg.15]

BVdU is degraded by thymidine phosphorylase more rapidly than the natural substrate, thymidine. This rapid enzymic degradation may present a problem in its clinical use. Moreover, herpes vimses develop resistance to BVdU, apparendy because of mutant vimses that have lower thymidine kinase activity. G. D. Seade has dropped further development of BVdU because of increased animal tumor incidence induced by prolonged dosing (1). [Pg.305]

Adenylate kinase rapidly interconverts ADP, ATP, and AMP to maintain this equilibrium. ADP levels in cells are typically 10% of ATP levels, and AMP levels are often less than 1% of the ATP concentration. Under such conditions, a small net change in ATP concentration due to ATP hydrolysis results in a much larger relative increase in the AMP levels because of adenylate kinase activity. [Pg.618]

FIGURE 23.22 The metabolic effects of insulin. As described in Chapter 34, binding of insulin to membrane receptors stimulates the protein kinase activity of the receptor. Subsequent phosphorylation of target proteins modulates the effects indicated. [Pg.760]

Bouaboula, M., Perrachon, S., Milligan, L., Canatt, X., Rinaldi-Carmona, M., Portier, M., Barth, F., Calandra, B., Pecceu, F., Lupker, J., Maffrand, J.-P., Le Fur, G., and Casellas, P. (1997). A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor. J. Biol. Ckem. 272 22330-22339. [Pg.58]

Phosphorylation is a common method of regulation. As described above, SH2 domains bind to phosphorylated tyrosine residues. Conversely, phosphorylation of serines and threonines proximal to SH3 and PDZ domains uncouples them from their target motifs. Therefore modulation of protein kinase activity in cells regulates interactions between adaptor proteins and their target proteins. [Pg.18]

Fluorid ions stimulate bone formation by a direct mitogenic effect on osteoblasts mediated via protein kinase activation and other pathways. Further to these cellular effects, fluorides alter hydroxyapatite crystals in the bone matrix. In low doses, fluorides induce lamellar bone, while at higher doses abnormal woven bone with inferior quality is formed. The effect of fluorides on normal and abnormal (e.g. osteoporotic) bone therefore depends on the dose administered. [Pg.282]

Inhibition of hematopoietic growth factors Imatinib (Glivec ) is applied to treat chronic myeloid leukemia in Philadelphia-chromosome positive patients. In these patients, translocation of parts of chromosomes 9 and 22 results in the expression of a fusion protein with increased tyrosine kinase activity, called Bcr-Abl. Imatinib is a small Mw inhibitor selective for the tyrosine kinase activity of Bcr-Abl. Thereby, it inhibits the Bcr-Abl induced cell cycle progression and the uncontrolled proliferation of tumor cells. [Pg.411]

Fluoride stimulates bone formation by protein kinase activation mediated effects on osteoblasts. Fluorides have been used in the treatment of osteoporosis, but their anti-fracture effect is not undisputed. [Pg.508]

Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling transient versus sustained extracellular signal-regulated kinase activation. Cell 80 179-185... [Pg.571]

Heterologous desensitization is a form of desensitization which does not require agonist binding of the receptor. Second messenger dependent kinases such as protein kinase A (PKA) and protein kinase C (PKC) are involved in this form of receptor desensitization. Heterologous desensitization simply depends on the overall kinase activity which is regulated by many different stimuli. [Pg.583]

Activation of the tyrosine kinase activity of the INSR is essential for the receptor function. The tyrosine kinase domain of the INSR is localized in the... [Pg.632]

Concanavalin A is a plant lectin from the jack bean (Canavalia ensiformis) which binds with high affinity to mannose residues of glycoproteins. Concanavalin A is known to stimulate the tyrosine kinase activity of the INSR (3-subunit with consecutive activation of kinases downstream the insulin receptor (IRS, PI 3-kinase). It is believed that Concanavalin A stimulates the activation and autophosphorylation of the INSR kinase through aggregation of the receptor, although the precise mechanism of action is unclear. [Pg.636]

Besides the cytokine receptors that lack intrinsic kinase activity but have associated JAK kinases, STAT proteins can be activated by a variety of G-protein coupled receptors and growth factor receptors with intrinsic tyrosine kinase activity (for example EGF, PDGF, CSF-1, and angiotensin receptor). Increasing evidence suggests a critical role for STAT family members in oncogenesis and aberrant cell proliferation. Constitutively activated STATs have been found in many transformed cell lines and a wide variety of human tumor entities. Numerous non-receptor tyrosine kinases and viral oncoproteins, such as v-Src, v-Abl, v-Sis, and v-Eyk, have been identified to induce DNA-binding activity of STAT proteins. [Pg.669]

Components of the JAK-STAT signaling pathway represent novel targets for pharmacological interventions [4]. Recently, a specific and orally active JAK3 antagonist was identified from screening of a chemical library for inhibitors of in vitro JAK3 kinase activity. The most effective compound, CP-690,550, was shown... [Pg.669]

Molecnles that Interfere with Receptor Tyrosine Kinase Activity... [Pg.1009]

Besides cytoplasmic protein kinases, membrane receptors can exert protein kinase activity. These so-called receptor tyrosine kinases (RTK) contain a ligandbinding extracellular domain, a transmembrane motif, and an intracellular catalytic domain with specificity for tyrosine residues. Upon ligand binding and subsequent receptor oligomerization, the tyrosine residues of the intracellular domain become phosphory-lated by the intrinsic tyrosine kinase activity of the receptor [3, 4]. The phosphotyrosine residues ftmction as docking sites for other proteins that will transmit the signal received by the RTK. [Pg.1009]


See other pages where Kinase activities is mentioned: [Pg.438]    [Pg.488]    [Pg.488]    [Pg.121]    [Pg.271]    [Pg.271]    [Pg.278]    [Pg.761]    [Pg.23]    [Pg.1]    [Pg.18]    [Pg.92]    [Pg.119]    [Pg.250]    [Pg.342]    [Pg.343]    [Pg.343]    [Pg.410]    [Pg.520]    [Pg.522]    [Pg.556]    [Pg.569]    [Pg.633]    [Pg.633]    [Pg.637]    [Pg.669]    [Pg.843]    [Pg.968]    [Pg.974]    [Pg.974]    [Pg.987]    [Pg.1010]    [Pg.1010]    [Pg.1099]   
See also in sourсe #XX -- [ Pg.143 ]




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AMP-activated kinase

AMP-activated protein kinase AMPK)

AMP-activated protein kinase activation

AMP-activated protein kinase activity

AMP-activated protein kinase system

Activated Protein (MAP) Kinase Inhibitors

Activated Protein Kinase Activity in Contractile Smooth Muscle

Activated Protein Kinases in Immune Response

Activation loop, kinases

Activation of Cytoplasmic Tyrosine Kinases

Active Inhibitor-insensitive Kinase Mutants (Orthogonal Protein Kinases)

Activities of phosphorylase kinase

Activities of protein kinases

Adenosine monophosphate-activated kinase

Adenosine monophosphate-activated protein kinase

Adenylate kinase catalytic activity

Aspartate kinase activation

CAMP-dependent protein kinase activation

CDC2 activating kinase

CDK-activating kinase

Calcium phosphorylase kinase activity

Calcium/calmodulin-dependent protein kinases activation

Calcium/calmodulin-dependent protein kinases activity regulation

Caldesmon mitogen-activated protein kinase

Calmodulin-activated protein kinase

Cell death tyrosine kinases activated apoptotic

Ceramide-activated kinase

Chimeric kinase activity sensors

Creatine kinase activation

Creatine kinase active site

Creatine kinase assay and specific activity, VIII

Cyclic AMP activated protein kinase

Cyclic AMP-dependent protein kinase activation

Cyclin-dependant kinases kinase activation

Cyclin-dependent kinase 4 , inhibitor activity against

Diacylglycerol protein kinase C activation

Diacylglycerols protein kinase activation

EGFR (epidermal growth factor kinase activation

ERK1/2, phosphorylation Mitogen-activated protein kinase

Effects of Mitogen-Activated Protein Kinases on T Cells

Enzyme mitogen activated protein kinases

Fructose 1,6-bisphosphate pyruvate kinase activation

Future developments kinase activation

Glycogen metabolism Kinase-activating factor

Homoserine kinase activation

Hormone-activated receptor tyrosine kinase

Imatinib nilotinib kinase activation

Insulin mitogen-activated protein kinase

Insulin receptor tyrosyl kinase activity

Insulin signalling activated protein kinase

JNK/stress-activated protein kinase

Janus kinase-signal transducer and activator

Janus kinase-signal transducers and activators of transcription

Janus kinase-signal transducers and activators of transcription JAK-STAT)

Janus-activated kinases

Jun N-terminal kinases activation

Kinase activated

Kinase activated

Kinase activation

Kinase catalytic activity

Kinases ceramide-activated protein kinase

MAP kinase activation

Mitogen -activated protein kinase (MAP

Mitogen activated protein kinase cascade

Mitogen-Activated Protein Kinase Activation in Contractile versus Proliferative Smooth Muscle

Mitogen-activated kinase

Mitogen-activated kinase cascade

Mitogen-activated kinase figure

Mitogen-activated protein kinase

Mitogen-activated protein kinase MAPK signaling

Mitogen-activated protein kinase MAPK) cascade

Mitogen-activated protein kinase Subject

Mitogen-activated protein kinase activation assays

Mitogen-activated protein kinase activity detection

Mitogen-activated protein kinase activity measurement

Mitogen-activated protein kinase caldesmon phosphorylation

Mitogen-activated protein kinase cell-surface receptors

Mitogen-activated protein kinase cellular mechanisms

Mitogen-activated protein kinase design

Mitogen-activated protein kinase growth factor receptor signaling

Mitogen-activated protein kinase inhibitors

Mitogen-activated protein kinase mitogens

Mitogen-activated protein kinase overview

Mitogen-activated protein kinase pathway

Mitogen-activated protein kinase pathway, tumor suppressor activities

Mitogen-activated protein kinase pharmacological

Mitogen-activated protein kinase phosphatases

Mitogen-activated protein kinase phosphorylation

Mitogen-activated protein kinase regulation

Mitogen-activated protein kinase signaling cascade

Mitogen-activated protein kinase signaling pathway

Mitogen-activated protein kinase smooth muscle activation

Mitogen-activated protein kinase substrate specificity

Mitogen-activated protein kinase system

Mitogen-activated protein kinase transcription factor signal-dependent

Mitogen-activated protein kinases MAPK)

Mitogen-activated protein kinases MAPKs)

Mitogen-activated protein kinases activation

Mitogen-activated protein kinases family

Mitogen-activated protein kinases immune response

Mitogen-activated protein kinases inhibition

Mitogen-activated protein kinases mammalian cells

Mitogen-activated protein kinases mechanisms

Mitogen-activated protein kinases translocation

Mitogen-activated protein kinases trichothecene activation

Mitogen-activated protein kinases, regulatory

Mitogen-activation protein kinase pathway

Mutations/drug resistance kinase activation

NH2-terminal kinase activity

Naturally occurring protein kinase activators

Nilotinib kinase activation

Nonreceptor tyrosine kinase Activation

P21-activated kinase

P21-activated protein kinases

P38 mitogen-activated protein kinase

P38 mitogen-activated protein kinase MAPK)

P38 mitogen-activated protein kinase MAPK) pathway

P42 mitogen-activated protein kinase

Phosphatidyl inositol phosphate-activated protein kinase

Phosphatidylinositol-3 kinases activation

Phosphoglycerate kinase activation

Phosphoglycerate kinase, activity

Phosphorylase kinase activity

Phosphorylase kinase, activation

Phosphorylases kinase active, inactive

Phosphorylation tyrosine kinase activity

Phosphotyrosine Content in Mitogen-Activated Protein Kinase

Platelet activating factor protein kinases

Platelet activation protein kinase

Platelet activation tyrosine kinase

Platelets activation: tyrosine kinase phosphorylation

Protein kinase A, activation

Protein kinase Activation by cAMP

Protein kinase C activator

Protein kinase C, activation

Protein kinase activation

Protein kinase activation, diacylglycerol

Protein kinase activation, effects

Protein kinase activities

Protein kinase activity detection after renaturation

Protein kinase activity regulation

Protein kinase activity sensors

Protein kinase cGMP-activated

Protein kinase constitutively active catalytic domain

Protein kinase, cAMP-dependent active sit

Protein kinases activated

Protein tyrosine kinases mitogen-activated

Protein tyrosine kinases, activation

Protein-tyrosine kinase activity

Protein-tyrosine kinase activity of Koelreuteria henryi

Protein-tyrosine kinase activity of flavonoid aglycones

Protein-tyrosine kinase activity of glycosides

Protein-tyrosine kinase inhibitory activities

Proteine kinase C activity

Pyruvate kinase activation

Pyruvate kinase activation volumes

Pyruvate kinase activators

Pyruvate kinase activity determination using

Pyruvate kinase, activity determinations

Pyruvate kinase, enzymic activity

Pyruvate kinase, enzymic activity liver metabolism

RNA-activated protein kinase

Raf kinase Activation

Ras-mitogen activated protein kinase

Receptor Activation, Tyrosine Kinase Activity, and in Cultured Vascular Smooth Muscle Cells

Receptor tyrosine kinase Activation

Receptor tyrosine kinase activity, insulin

Receptors with Associated Tyrosine Kinase Activity

Receptors with Kinase Activity

Receptors with protein kinase activity

Receptors with serine/threonine kinase activity

Receptors with tyrosine kinase activity

Recognition-domain-focused kinase activity

Recognition-domain-focused kinase activity sensors

Redox regulation kinase activity

Regulation of Calmodulin-Kinase II Activity

Regulation of Protein Kinase C Activity

Signal Transmission via Transmembrane Receptors with Tyrosine-specific Protein Kinase Activity

Signal mitogen activated protein kinase

Signal transduction cAMP-dependent protein kinase activation

Signal transduction mitogen-activated protein kinase

Signaling mitogen-activated protein kinases

Smooth muscle activation kinase cascades

Smooth muscle activation other kinases

Smooth muscle activation protein kinase

Sorafenib kinase activation

Sox-containing kinase activity sensors

Stress Activated and Extra-cellular Kinases

Stress activated protein kinase, SAPK

Stress activated protein kinases gene expression regulated

Stress-activated kinases

Stress-activated protein kinase family

Stress-activated protein kinases

Stress-activated protein kinases SAPKs)

Structure and Activation of Protein Kinase

Structure and Activation of the Tyrosine Kinase Domain

Sunitinib kinase activation

The General Structure of an Activated Kinase

The Janus Family Tyrosine Kinases-Signal Transducers and Activators of Transcription Signaling Pathway

Treatment mitogen-activated protein kinase inhibitors

Trichothecenes mitogen-activated protein kinases

Tyrosine kinase activity

Tyrosine kinase inhibitors biological activity

Xestocylamine activity inhibition of protein kinase

Xestoquinolide protein kinase activity

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