CDK-activating kinase

Not included are other protein kinases present in diverse tissues, including brain, that play a role in generalized cellular processes, such as intermediary metabolism, and that may not play a role in neuron-specific phenomena. CAK, CDK-activating kinase ... 

Shiekhattar, R., Mermelstein, E, Eisher, R.P., Drapkin, R., Dynlacht, B., Wessling, H.C., Morgan, D.O. and Reinberg, D. Cdk-activating kinase complex is a component of human transcription factor TEIIH (1995) Nature 374, 283-287... 

Figure 2. Schematic representation of the activation of the cdk4/cyclin D complex during Gl. Evidence shows that CaMKIa, which can be activated by either CaMKKa or (3, activates the cdk4/cyclin D complex, leading to the phosphorylation of Rb and therefore de-repression of E2F transcription factor members. The mechanism by which CaMKI regulates cdk4/cyclin D remains to be determined. GFR, receptor for a growth factor CAK, cdk activating kinase p21/p27, members of the inhibitory Cip and Kip families, respectively E2F 1-3, transcription factors 1-3 of die E2F family Rb, Retinoblastoma protein P, phosphorylation event...

Fisher RP, Morgan DO (1994) Anovel cyclin associates with M015/CDK7 to form the CDK-activating kinase. Cell 78(4) 713-724... 

Shiekhattar R, Mermelstein F, Fisher RP et al (1995) Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374(6519) 283-287 Waters NC, Woodard CL, Prigge ST (2000) Cyclin H activation and drug susceptibility of the Pfinrk cyclin dependent protein kinase from Plasmodium falciparum. Mol Biochem Parasitol 107(l) 45-55 Xiao Z, Waters NC, Woodard CL et al (2001) Design and synthesis of Pfinrk inhibitors as potential antimalarial agents. Bioorg Med Chem Lett ll(21) 2875-2878 Woodard CL, Li Z, Kathcart AKet al (2003) Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases. J Med Chem 46(18) 3877-3882... 

M. Rossignol, I. Kolb-Cheynel, and J.-M. i ly. Substrate specificity of the Cdk-activating kinase (CAK), is altered upon association with TFUH. EMBOJ, 16, 1628—1637, 1997. 

CAKs are Cdk-activating kinases. They are apparently constitutively active, so that activation of Cdk by CAKs is controlled primarily by the accessibility of phosphorylation sites in the cyclin-Cdk complex to CAKs. Activation is the consequence of phosphorylation of... 

Mnltifunctional protein which initiates and regnlates de novo pyrimidine biosynthesis caspases-activated DNAse Cdk-activating kinase... 

Aprelikova O, Xiong Y, Liu ET. Both pi6 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase. J. 

Kaldis, P. (1999) The cdk-activating kinase (CAK) from yeast to mammals. Cell Mol.Life Sci., 55, 284-296. 

Figure 21-14 illustrates the functions of four proteins that regulate the protein kinase activity of the 5. pombe CDK. First is Cdcl3, the mitotic cyclin of S. pombe (equivalent to cyclin B in metazoans), which associates with the CDK to form MPF with extremely low activity. Second is the Weel protein-tyrosine kinase, which phosphorylates an inhibitory tyrosine residue (Y15) in the CDK subunit. Third is another kinase, designated CDK-activating kinase (CAK), which phosphorylates an activating threonine residue (T161). When... 

Makela, T.P., J.-P. Tassan, E.A. Nigg, S. Frutiger, G.J. Hughes R.A. Weinberg. 1994. A cyclin associated with the CDK-activating kinase M015. Nature 371 254-7. 

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