Heterologous desensitization

Heterodimeric receptors, 182t Hetero dimerization, 181 Heterologous desensitization, 34 High-throughput screening agonists, 156 antagonists, 156... 

Heterologous desensitization is a form of desensitization which does not require agonist binding of the receptor. Second messenger dependent kinases such as protein kinase A (PKA) and protein kinase C (PKC) are involved in this form of receptor desensitization. Heterologous desensitization simply depends on the overall kinase activity which is regulated by many different stimuli. 

Heparin Sulfate Proteoglycans Hepatic Lipase Hepatitis Hepatitis C Heptahelical Domain Heptahelical Receptors HERG-channels Heterologous Desensitization Heterologous Expression System Heterotrimeric G-Proteins Hidden Markov Model High-density Lipoprotein (HDL)... 

Hecht I, Cahalon L, Hershkoviz R, Lahat A, Franitza S, Lider O (2003) Heterologous desensitization of T ceU functions by CCR5 and CXCR4 ligands inhibition of ceUular signaling, adhesion and chemotaxis. Int Immunol 15 29-38... 

In this chapter, we review the interactions at the level of protein function, between opioid receptors and chemokine receptors, using both in vitro and in vivo model systems. As a part of this discussion, we also describe our current understanding of the biochemical pathway(s) that are involved in the heterologous desensitization process between these groups of receptors. 

Molecular Mechanism of Heterologous Desensitization between Opioid and Chemokine Receptors... 

Giimm MC, Ben-Baruch A, Taub DD, Howard OM, Resau JH, Wang JM (1998) Opiates transde-activate chemokine receptors delta and mu opiate receptor-mediated heterologous desensitization. J Exp Med 188(2) 317-325... 

Premont, R., Jacobowitz, O. and Iyengar, R. Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by Gs in heterologous desensitization a role for cAMP dependent phosphorylation. Endocrinology 131 2774-2783,... 

Phosphorylation of the -adrenergic receptor by PKA can be viewed as a classical example of negative feedback activation of the receptor stimulates intracellular cascades that feed back to reduce further receptor activation. Phosphorylation of the receptor by PKA could also mediate heterologous desensitization of the receptor any neu-rotransmitter-receptor system that works through cAMP would be expected to stimulate P-adrenergic receptor phosphorylation via PKA and lead to receptor desensitization. This is one mechanism by which one neurotrans-mitter-receptor system can affect another. 

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