Pharmacologic intervention

The basis for believing the pharmacological intervention can be a major approach to the treatment of disease is the fact that the body generally functions in response to chemicals. Table 1.1 shows partial lists of hormones and neuro transmitters in the body. Many more endogenous chemicals are involved in normal physiological function. The fact that so many physiological processes are controlled by chemicals provides... 

DOX, as EPI seems to form fewer amounts of ROS and secondary alcohol metabolite, (ii) encapsulation of anthracyclines in uncoated or pegylated liposomes that ensure a good drug delivery to the tumor but not to the heart, (iii) conjugation of anthracyclines with chemical moieties that are selectively recognized by the tumor cells, (iv) coadministration of dexrazoxane, an iron chelator that diminishes the disturbances of iron metabolism and free radical formation in the heart, and (v) administration of anthracyclines by slow infusion rather than 5-10 min bolus (Table 1). Pharmacological interventions with antioxidants have also been considered, but the available clinical studies do not attest to an efficacy of this strategy. 

Several pharmacological interventions target bile acid homeostasis. 

Treatment of drug addicts can be sqDarated into two phases detoxification and relapse prevention. Detoxification programs and treatment of physical withdrawal symptoms, respectively, is clinically routine for most drugs of abuse. However, pharmacological intervention programs for relapse prevention are still not veiy efficient. 

Endocannabinoids. Table 1 Changes of endocannabinoid levels during pathological conditions and subsequent possible pharmacological interventions... 

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