Mitogen-activated protein kinase Subject

Like the other two a2-AR subtypes, the site for polymorphic variation of the a2C-AR is localized to the third intracellular loop (1) (Fig. 1). For this subtype, a 12-nucleotide in-frame deletion resulting in a four-amino acid (Gly-Ala-Gly-Pro) loss has been detected, primarily in subjects of African descent (Table 1). In CHO cells, the a2C-Del322-325 displays markedly depressed function as assessed by inhibition of adenylyl cyclase (Fig. 10), stimulation of mitogen-activated protein kinase p44/42, and stimulation of inositol phosphates (1). The basis for this impairment is not clear. Although the third intracellular loop is... 

Belfiore, F, Romeo, F, Napoli, E, and Lo Vecchio, L, Enzymes of glucose metabolism in liver of subjects with adult-onset diabetes. Diabetes, 1974. 23(4) 293-301. Benbow, U, Tower, GB, Wyatt, CA, Buttice, G, and Brinckerhoff, CE, High levels of mmp-1 expression in the absence of the 2g single nucleotide polymorphism is mediated by p38 and erkl/2 mitogen-activated protein kinases in vmm5 melanoma cells, J Cell Biochem, 2002. 86(2) 307-319. 

Apart from direct activation via ligand binding, nuclear receptors are also subject to regulation by phosphorylation. Thus, transcriptional activity of PPARy can be regulated by growth factor stimulation via the mitogen-activated protein (MAP) kinase pathway (34). 

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