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Protein kinase activation

This method has been successfully applied to the substituted indole 2.6B, an analogue of the teleocidin type of protein kinase activators[ll]. [Pg.15]

FIGURE 23.22 The metabolic effects of insulin. As described in Chapter 34, binding of insulin to membrane receptors stimulates the protein kinase activity of the receptor. Subsequent phosphorylation of target proteins modulates the effects indicated. [Pg.760]

Bouaboula, M., Perrachon, S., Milligan, L., Canatt, X., Rinaldi-Carmona, M., Portier, M., Barth, F., Calandra, B., Pecceu, F., Lupker, J., Maffrand, J.-P., Le Fur, G., and Casellas, P. (1997). A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor. J. Biol. Ckem. 272 22330-22339. [Pg.58]

Phosphorylation is a common method of regulation. As described above, SH2 domains bind to phosphorylated tyrosine residues. Conversely, phosphorylation of serines and threonines proximal to SH3 and PDZ domains uncouples them from their target motifs. Therefore modulation of protein kinase activity in cells regulates interactions between adaptor proteins and their target proteins. [Pg.18]

Fluorid ions stimulate bone formation by a direct mitogenic effect on osteoblasts mediated via protein kinase activation and other pathways. Further to these cellular effects, fluorides alter hydroxyapatite crystals in the bone matrix. In low doses, fluorides induce lamellar bone, while at higher doses abnormal woven bone with inferior quality is formed. The effect of fluorides on normal and abnormal (e.g. osteoporotic) bone therefore depends on the dose administered. [Pg.282]

Fluoride stimulates bone formation by protein kinase activation mediated effects on osteoblasts. Fluorides have been used in the treatment of osteoporosis, but their anti-fracture effect is not undisputed. [Pg.508]

Besides cytoplasmic protein kinases, membrane receptors can exert protein kinase activity. These so-called receptor tyrosine kinases (RTK) contain a ligandbinding extracellular domain, a transmembrane motif, and an intracellular catalytic domain with specificity for tyrosine residues. Upon ligand binding and subsequent receptor oligomerization, the tyrosine residues of the intracellular domain become phosphory-lated by the intrinsic tyrosine kinase activity of the receptor [3, 4]. The phosphotyrosine residues ftmction as docking sites for other proteins that will transmit the signal received by the RTK. [Pg.1009]

Jurivich, D. A., Chung, J., Blenis, J. (1991). Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts. J. Cell. Physiol. 148,252-259. [Pg.455]

Protein kinase activities wete originally described as being cAMP-dependent or cAMP-independent. This... [Pg.460]

II. PROTEIN KINASE ACTIVITY AND REGULATION OF CELL CYCLE EVENTS IN THE YEAST AND SELECTED VERTEBRATE MODEL SYSTEMS... [Pg.4]

B. Regulators of Cdc2/Cdk2 Protein Kinase Activity Cyclins... [Pg.8]

Choi, T., Aoki, E, Mori, M., Yamashita, M., Nagahama, Y., and Kohmoto, K. (1991). Activation of p34nfc2 protein kinase activity in meiotic and mitotic cell cycles in mouse oocytes and embryos. Development 113 789-795. [Pg.37]

Morrison, D. K., Kaplan, D. R., Rapp, U., and Roberts, T. M. (1988). Signal transduction from membrane to cytoplasm growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc. Natl. Acad. Sci. USA 85 8855-8859. [Pg.46]

Stokoe, D., Campbell, D. G., Nakielny, S., Hidaka, H., Leevers, S. J., Marshall, C., and Cohen, P. (1992). MAPKAPkinase-2 a novel protein kinase activated by mitogen-activated protein kinase. EMBO J. 11 3985-3994. [Pg.51]

Bode, A.M. and Dong, Z. 2003. Mitogen-activated protein kinase activation in UV-induced signal transduction. [Pg.479]

Nestler E. Under seige the brain and opiates. Neuron 1996 16 897—900. Nestler E, Tallman J. Chronic morphine treatment increases cAMP dependent protein kinase activity in the rat locus coeruleus. Mol Pharmacol 1988 33 127-132. [Pg.485]

Hitti, E., Iakovleva, T., Brook, M., Deppenmeier, S., Gruber, A. D., Radzioch, D., Clark, A. R., Blackshear, P. J., Kotlyarov, A., and Gaestel, M. (2006). Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol. Cell Biol. 26, 2399—2407. [Pg.173]

Lali, F. V., Hunt, A. E., Turner, S. J., and Foxwell, B. M. (2000). The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independendy ofp38 mitogen-activated protein kinase. J. Biol. Chem. 275, 7395-7402. [Pg.173]

Poteet-Smith, C. E., Smith, J. A., Lannigan, D. A., Freed, T. A., and Sturgill, T. W. (1999). Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family. J. Biol. Chem. 274, 22135-22138. [Pg.174]

Sharma, V., Wang, Q. and Lawrence, D. S. (2008). Peptide-based fluorescent sensors of protein kinase activity Design and applications. Biochim Biophys. Acta. 1784, 94—99. [Pg.299]


See other pages where Protein kinase activation is mentioned: [Pg.438]    [Pg.488]    [Pg.488]    [Pg.761]    [Pg.974]    [Pg.974]    [Pg.1010]    [Pg.1206]    [Pg.421]    [Pg.428]    [Pg.103]    [Pg.215]    [Pg.436]    [Pg.366]    [Pg.358]    [Pg.3]    [Pg.27]    [Pg.132]    [Pg.466]    [Pg.156]    [Pg.297]    [Pg.297]   
See also in sourсe #XX -- [ Pg.261 ]

See also in sourсe #XX -- [ Pg.160 ]

See also in sourсe #XX -- [ Pg.185 ]

See also in sourсe #XX -- [ Pg.241 , Pg.270 , Pg.279 ]




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AMP-activated protein kinase AMPK)

AMP-activated protein kinase activation

AMP-activated protein kinase activity

AMP-activated protein kinase system

Activated Protein (MAP) Kinase Inhibitors

Activated Protein Kinase Activity in Contractile Smooth Muscle

Activated Protein Kinases in Immune Response

Active Inhibitor-insensitive Kinase Mutants (Orthogonal Protein Kinases)

Activities of protein kinases

Adenosine monophosphate-activated protein kinase

CAMP-dependent protein kinase activation

Calcium/calmodulin-dependent protein kinases activation

Calcium/calmodulin-dependent protein kinases activity regulation

Caldesmon mitogen-activated protein kinase

Calmodulin-activated protein kinase

Cyclic AMP activated protein kinase

Cyclic AMP-dependent protein kinase activation

Diacylglycerol protein kinase C activation

Diacylglycerols protein kinase activation

ERK1/2, phosphorylation Mitogen-activated protein kinase

Effects of Mitogen-Activated Protein Kinases on T Cells

Enzyme mitogen activated protein kinases

Insulin mitogen-activated protein kinase

Insulin signalling activated protein kinase

JNK/stress-activated protein kinase

Kinase activated

Kinase activity

Kinases ceramide-activated protein kinase

Mitogen -activated protein kinase (MAP

Mitogen activated protein kinase cascade

Mitogen-Activated Protein Kinase Activation in Contractile versus Proliferative Smooth Muscle

Mitogen-activated protein kinase

Mitogen-activated protein kinase MAPK signaling

Mitogen-activated protein kinase MAPK) cascade

Mitogen-activated protein kinase Subject

Mitogen-activated protein kinase activation assays

Mitogen-activated protein kinase activity detection

Mitogen-activated protein kinase activity measurement

Mitogen-activated protein kinase caldesmon phosphorylation

Mitogen-activated protein kinase cell-surface receptors

Mitogen-activated protein kinase cellular mechanisms

Mitogen-activated protein kinase design

Mitogen-activated protein kinase growth factor receptor signaling

Mitogen-activated protein kinase inhibitors

Mitogen-activated protein kinase mitogens

Mitogen-activated protein kinase overview

Mitogen-activated protein kinase pathway

Mitogen-activated protein kinase pathway, tumor suppressor activities

Mitogen-activated protein kinase pharmacological

Mitogen-activated protein kinase phosphatases

Mitogen-activated protein kinase phosphorylation

Mitogen-activated protein kinase regulation

Mitogen-activated protein kinase signaling cascade

Mitogen-activated protein kinase signaling pathway

Mitogen-activated protein kinase smooth muscle activation

Mitogen-activated protein kinase substrate specificity

Mitogen-activated protein kinase system

Mitogen-activated protein kinase transcription factor signal-dependent

Mitogen-activated protein kinases MAPK)

Mitogen-activated protein kinases MAPKs)

Mitogen-activated protein kinases activation

Mitogen-activated protein kinases family

Mitogen-activated protein kinases immune response

Mitogen-activated protein kinases inhibition

Mitogen-activated protein kinases mammalian cells

Mitogen-activated protein kinases mechanisms

Mitogen-activated protein kinases translocation

Mitogen-activated protein kinases trichothecene activation

Mitogen-activated protein kinases, regulatory

Mitogen-activation protein kinase pathway

Naturally occurring protein kinase activators

P21-activated protein kinases

P38 mitogen-activated protein kinase

P38 mitogen-activated protein kinase MAPK)

P38 mitogen-activated protein kinase MAPK) pathway

P42 mitogen-activated protein kinase

Phosphatidyl inositol phosphate-activated protein kinase

Phosphotyrosine Content in Mitogen-Activated Protein Kinase

Platelet activating factor protein kinases

Platelet activation protein kinase

Protein kinase A, activation

Protein kinase Activation by cAMP

Protein kinase C activator

Protein kinase C, activation

Protein kinase activation, diacylglycerol

Protein kinase activation, effects

Protein kinase activities

Protein kinase activity detection after renaturation

Protein kinase activity regulation

Protein kinase activity sensors

Protein kinase cGMP-activated

Protein kinase constitutively active catalytic domain

Protein kinase, cAMP-dependent active sit

Protein kinases activated

Protein tyrosine kinases mitogen-activated

Protein tyrosine kinases, activation

Protein-tyrosine kinase activity

Protein-tyrosine kinase activity of Koelreuteria henryi

Protein-tyrosine kinase activity of flavonoid aglycones

Protein-tyrosine kinase activity of glycosides

Protein-tyrosine kinase inhibitory activities

Proteine kinase C activity

RNA-activated protein kinase

Ras-mitogen activated protein kinase

Receptors with protein kinase activity

Regulation of Protein Kinase C Activity

Signal Transmission via Transmembrane Receptors with Tyrosine-specific Protein Kinase Activity

Signal mitogen activated protein kinase

Signal transduction cAMP-dependent protein kinase activation

Signal transduction mitogen-activated protein kinase

Signaling mitogen-activated protein kinases

Smooth muscle activation protein kinase

Stress activated protein kinase, SAPK

Stress activated protein kinases gene expression regulated

Stress-activated protein kinase family

Stress-activated protein kinases

Stress-activated protein kinases SAPKs)

Structure and Activation of Protein Kinase

Treatment mitogen-activated protein kinase inhibitors

Trichothecenes mitogen-activated protein kinases

Xestocylamine activity inhibition of protein kinase

Xestoquinolide protein kinase activity

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