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Cyclin-dependent kinase 4 , inhibitor activity against

UCN-01 [20] (http //www.novartisoncology.com/research-innovatiOTi/pipeline. jsp) also known as 7-hydroxystaurosporine, is a non-specific inhibitor of kinases with good activity against PKC, the cyclin-dependent kinases (CDKs) and checkpoint kinase I (Chkl), and it is in phase II studies for the potential treatment of cancer - in particular chronic lymphocytic leukemia. [Pg.19]

Mukai and co-workers used a reduction/cyclization cascade to prepare (-)-nakadomarin, a manzamine-related alkaloid with cytotoxic activity, inhibitor activity against cyclin-dependent kinase 4 (CDK-4), and anti-fungal and antibacterial activity. Treatment of the tetracyclic precursor with DIBAL-H followed by reaction with HCl led to the desired pentacyclic system in 41% yield. [Pg.130]

See other pages where Cyclin-dependent kinase 4 , inhibitor activity against is mentioned: [Pg.578]    [Pg.308]    [Pg.375]    [Pg.94]    [Pg.20]    [Pg.133]    [Pg.62]    [Pg.391]    [Pg.193]    [Pg.209]    [Pg.365]    [Pg.447]    [Pg.126]    [Pg.305]    [Pg.374]    [Pg.31]    [Pg.535]    [Pg.535]    [Pg.56]    [Pg.229]    [Pg.46]    [Pg.361]    [Pg.428]   
See also in sourсe #XX -- [ Pg.130 ]



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Cyclin

Cyclin dependent kinase inhibitors

Cyclin-dependant kinase inhibitor

Cyclin-dependant kinases

Cyclin-dependant kinases kinase activation

Cyclin-dependent

Cycline-dependent kinases

Cyclins

Cyclins cyclin

Kinase activated

Kinase activity

Kinase inhibitors

Kinase, kinases inhibitors

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