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Protein targets

Moleeular biology eloning expression isotope labeling of protein target... [Pg.274]

Small ubiquitous calcium-binding protein. Calmodulin binds and regulates the activity of many protein targets involved in cellular signal transduction pathways mediated by calcium. Calmodulin is ranked among the most conserved proteins and plays a key role in many cellular processes. [Pg.311]

If structural information of the protein target is available, e.g., a crystal structure, in silico screening of huge virtual compound libraries can be conducted by the use of docking simulations. Based on identified primary hits, structural variations of the ligand can be evaluated by computational modeling of the ligand-protein complex. [Pg.384]

Dalbey RE, von Heijne G (eds) (2002) Protein targeting, transport, and translocation. Academic Press, London... [Pg.1019]

Venter, K. (1992). Early events in yeast mitochondrial protein targeting. Mol. Microbiol. 6,1723-1728. [Pg.154]

Richards, R, Johnson, M., Ray, D., and Walker, C.H. (1999). Novel protein targets for organophosphorous compounds. In Esterases Reacting with Organophosphorous Compounds. E. Reiner, V. Simeon-Rudolf, and B.P. Doctor et al. (Eds.) Special Issue of Chemico-Biological Interactions 119-120. [Pg.366]

As the availability of crystal structures increased in the early 1990s, a number of experimental and computational methods were developed to use the structure of the protein target as a route to discover novel hit compounds. The methods include de novo design, virtual screening, and fragment-based discovery. These developments are covered in more detail in the later chapters of this book, but their main features can be summarized as follows. [Pg.284]

Greer J, Erickson JW, Baldwin, JJ, Varney MO. Application of three-dimensional structures of protein target molecules in structure-based drug design. J Med Chem 1994 37 1035-54. [Pg.297]

To maximize safety and therapeutic efficacy, potential drugs are required to be highly specific for their protein target and orally bioavailable. In addition, for a drug candidate to reach the market, it must be patentably novel. A computational approach therefore needs to find novel compounds with well-defined pharmacological properties from the vast space of possible organic compounds ( chemical space ). [Pg.323]

A necessary condition for a compound to exhibit in vivo efficacy is in vitro activity. By activity, we mean that the compound is able to demonstrate binding to the protein target of interest. At constant pressure and temperature, the protein (P) and ligand (L) binding free energy is given by... [Pg.347]

Two distinct strategies are used in NMR screening. The first strategy looks for changes in the NMR spectrum of the protein target and the second looks for changes to the NMR spectrum of the ligand. [Pg.18]

A simple NMR technique, and arguably the most widely used and effective for hit validation, is the chemical shift perturbation method. In this approach, a reference spectrum of isotopically labeled target is recorded in absence and presence of a given test ligand (or a mixture of test ligands). Commonly, differences in chemical shift between free and bound protein target are observed in 2D [15N, 1H and/or 2D [13C, H] correlation spectra of a protein (or nucleic acid) upon titration of a ligand... [Pg.130]

Table 1 List of Possible Protein Targets for Therapeutic Intervention... [Pg.33]


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See also in sourсe #XX -- [ Pg.323 ]

See also in sourсe #XX -- [ Pg.187 , Pg.188 ]




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Bacterial proteins, target peptides

Calmodulin, binding target enzymes/proteins

Cellular retinoic acid binding proteins gene targeting

Computational protein design target structures

Detection of target proteins

Drug targets allosteric proteins

Drug targets, protein kinases

Endoplasmic reticulum protein targeting from

Eukaryotes protein targeting

Eukaryotic Proteins Targeted for Secretion Are Synthesized in the Endoplasmic Reticulum

Finding protein targets

Folding of an Intrinsically Disordered Protein Upon Binding to a Target

Foreign protein accumulation, target

Functional group targets proteins

Functional targets Proteins

Glycogen targeting protein subunit

H4 Protein targeting

HMGA proteins as potential drug targets

Heat shock proteins, molecular targets

Labeling of the Target Protein

MRNA profiling protein targets

Membrane transport proteins targeting

Membrane transport proteins targetting

Methotrexate , target protein

Mitochondrial targeting signals inner membrane proteins

Mitochondrial targeting signals intermembrane space proteins

Mitochondrial targeting signals matrix proteins

Mitochondrial targeting signals membrane proteins

Monoclonal antibodies targeted against protein mediators

Monoclonal antibodies targeted against receptor proteins

Mucosally targeted protein

Non-Protein Kinases as Therapeutic Targets

Oligonucleotides: Superspecific Ligand for Targeting Nucleic Acids and Proteins

Organometallic Compounds Targeting Specific Protein Residues

Other Target Proteins

Peptides that bound target proteins

Peroxisomes, protein targeting signals

Peroxisomes, protein targeting signals matrix proteins

Peroxisomes, protein targeting signals membrane proteins

Phage display technique, target protein

Phage display technique, target protein identification

Pharmacological Endpoint Reduction of Target mRNA and Protein

Protein Signal sequence Targeting

Protein Synthesis, Targeting, and Turnover

Protein Targeting and Processing

Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications

Protein design target structures

Protein force fields target data

Protein identify peptides that bound target

Protein kinases as drug targets

Protein kinases inhibitors/drug targets

Protein phosphatases targeting subunits

Protein sequence-structure target proteins

Protein target isoform selective inhibitor

Protein target-based virtual screening

Protein targeting

Protein targeting

Protein targeting KDEL signal

Protein targeting chaperones

Protein targeting endoplasmic reticulum proteins

Protein targeting exocytosis

Protein targeting integral membrane proteins

Protein targeting lysosomal proteins

Protein targeting mannose 6-phosphate signal

Protein targeting membrane-spanning proteins

Protein targeting mitochondrial proteins

Protein targeting nuclear localization signal

Protein targeting nuclear proteins

Protein targeting overview

Protein targeting plasma membrane proteins

Protein targeting proteins)

Protein targeting proteins)

Protein targeting receptor-mediated endocytosis

Protein targeting secretory proteins

Protein targeting signal peptidase

Protein targeting signal recognition particle

Protein targeting signal sequence (secretory

Protein targeting, transgene

Protein targets, hydrogen bonding interactions

Protein targets, number

Protein turnover targeting

Protein-ligand binding affinity target proteins

Protein-ligand interactions targets

Proteins Are Targeted to Their Destination by Signal Sequences

Proteins as Drugs and Drug Design Targets Enzymes

Proteins as Drugs and Drug Design Targets Non-Enzymes

Proteins targeted

Proteins targeted

Proteome analysis differential protein targeting

RGS4 Protein Target

Selective Targeting of Protein Interactions Mediated by BET Bromodomains

Solvent Accessibility of Functional Targets in Proteins

Target Cells for Macrophage Stimulating Protein

Target Family Landscapes of Protein Kinases

Target Protein(s) of Centrocountin

Target Proteins by CCT

Target family proteins, clustering

Target for Inhibition of Protein Synthesis

Target of Rapamycin proteins

Target proteins identification

Target proteins selection

Target proteins small molecule data

Target proteins targets

Target-Based Virtual Screening on Small-Molecule Protein Binding Sites

Targeted Biomarker Detection Via Whole Protein Analysis

Targeted Delivery of Proteins to Specific Tissue Regions

Targeted Intracellular Protein Degradation as a Potential Therapeutic Strategy

Targeting Cell Membrane Proteins Ligand-Gated Ion Channels

Targeting Cell Membrane Structures Protein Component

The Chimaeric Origin of Mitochondrial Protein Import and Targeting

The G Protein Cycle Is a Target for Certain Bacterial Toxins

Translation protein targeting

Transport proteins, drug targets

Unfolded protein response targets

Unique De-wetting Hot Spots in the Target Protein Provide a Blueprint for Drug Design

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