Smooth muscle activation mitogen-activated protein kinase

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Geraldes R Sirois MG, Bernatchez PN, Tanguay JE Estrogen regulation of endothelial and smooth muscle cell migration and proliferation role of p38 and p42/44 mitogen-activated protein kinase. Arterioscler Thromb Vase Biol 2002 22 1585-1590. 

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Eguchi, S., Matsumoto, T., Motley, E. D., et al. 1996. Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. Possible requirement of Gq-mediated p21ras activation coupled to a Ca2+/calmodulin-sensitive tyrosine kinase. J Biol Chem 271 14169-14175. 

Eguchi, S., Numaguchi, K., Iwasaki, H., et al. 1998. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J Biol Chem 273 8890-8896. 

Ushio-Fukai, M., Alexander, R. W., Akers, M., et al. 1998a. p38 mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy. J Biol Chem 273 15022-15029. 

Eguchi, S., Numaguchi, K., Iwasaki, H., Matsumoto, T., Yamakawa, T., Utsunomiya, H., Motley, E.D., Kawakatsu, H., Owada, K.M., Hirata, Y., Marumo, F., and Inagami, T. 1998. Calcium-dependent epidermal growth factor receptor transactivaiton mediates the angiotensin Il-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J. Biol. Chem. 273 8890-8896. 

Tabet, F., E.L. Schiffrin, and R.M. Touyz. 2005. Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells upregulation in spontaneously hypertensive rats. J. Hypertens. 23 2005-2012. 

H. Satoh, M. Togo, M. Hara, T. Miyata, K. Han, H. Maekawa, N. Ohno, Y. Hashimoto, K. Kurokawa, and T. Watanabe, Advanced glycation endproducts stimulate mitogen-activated protein kinase and proliferation in rabbit vascular smooth muscle cells, Biochem. Biophys. Res. Comm., 1997, 239, 111-115. 

Inhibits NAD(P)H oxidase cytochrome b558 activity, increases oxidant production by the mitochondria and inhibits ASMC proliferation and phosphorylation of the ERK1/2 mitogen-activated protein kinase and expression of cyclin D1 in human airway smooth muscle [74]... 

Hu ZW, Shi XY, Lin RZ, Chen J, Hoffman BB. ar Adrenergic receptor stimulation of mitogenesis in human vascular smooth muscle cells role of tyrosine protein kinases and calcium in activation of mitogen-activated protein kinase. J Pharmacol Exp Ther 1999 290 28-37. 

Fig. 13.3 Signaling pathways involved in oxidized phospholipid-induced apoptosis in mammalian smooth muscle and endothelial cells. AIF, apoptosis inducing factor Apaf-1, apoptosis activating factor 1 aSM, acid sphingomyelinase Az-PC azelaoyl acid ester of lyso-PC Cyt c, cytochrome c G-PC, glutaric acid ester of lyso-PC IM, intermembrane space of the mitochondria JNK, c-Jun N-terminal kinase OV-PC, 5-oxovaleric acid ester of lyso-PC p38, p38 mitogen-activated protein kinase PM, plasma membrane...

II. MEASUREMENT OF MITOGEN-ACTIVATED PROTEIN KINASE ACTIVITY IN SMOOTH MUSCLE... 

D. Cytochemical Localization of Mitogen-Activated Protein Kinase in Arterial Smooth Muscle... 

The significance of CD phosphorylation is further evidenced by the work of Adam et al. (1995b), which demonstrated that the level of mitogen-activated protein kinase (MAPK), the enzyme presumably involved in CD phosphorylation in vivo, is regulated in response to both mechanical load and pharmacological stimulation. Further work will likely delineate the precise role of CD phosphorylation in smooth muscle. 

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