Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Active Inhibitor-insensitive Kinase Mutants Orthogonal Protein Kinases

3 Active Inhibitor-insensitive Kinase Mutants (Orthogonal Protein Kinases) [Pg.179]

ATP-site competitors typically exploit the steric space in the hydrophobic back pocket. By mutating a small amino acid in the back pocket into one with a bulkier residue, inhibitor binding is abolished, typically without affecting the specific activity of the kinase reaction. [Pg.180]




SEARCH



Inhibitor-insensitive kinase

Insensitive

Insensitivity

Kinase activated

Kinase activity

Kinase inhibitors

Kinase mutants

Kinase orthogonal inhibitors

Kinase, kinases inhibitor-insensitive

Kinase, kinases inhibitors

Kinase, kinases orthogonal

Mutants, inhibitor-insensitive

Orthogonal activation

Protein inhibitor

Protein kinase activation

Protein kinase inhibitors

© 2024 chempedia.info