Cell death tyrosine kinases activated apoptotic

In an in vitro model, exposure of lymphoma cells to rituximab resulted in the activation of the Src-family of protein tyrosine kinases (13), leading to the phosphorylation of PLCy2, which induces calcium influx and activates caspase 3, resulting in promotion of apoptotic cell death (8,14). Another in vitro model showed that exposure to rituximab resulted in the sustained phosphorylation of p38-MAPK, JNK, and ERK kinases... 

Modulation of MAPKs by flavonoid polyphenols such as kaempferol and genistein has been shown [182]. Huang et al. reported that genistein inhibited TGF-p-mediated p38 MAP kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells at concentrations associated with dietary consumption [183]. In other studies, genistein has been found effective in preventing cytokine-induced ERKl/2 activation and promoting apoptotic cell death [184]. Since genistein is a well-known inhibitor of tyrosine kinase, it is... 

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