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Growth factors insulin-like

The IGFs (also termed somatomedins ), constitute a family of two closely related (small) polypeptides IGF-I and IGF-II. As the names suggest, these growth factors bear a strong structural resemblance to insulin (or, more accurately, proinsulin). Infusion of IGF-I decreases circulating [Pg.280]

Foetal development promotes growth and differentiation of foetal cells and organogenesis Promotes longitudinal body growth and increased body weight Promotes enhanced functioning of the male and female reproductive tissue Promotes growth and differentiation of neuronal tissue [Pg.281]

The liver represents the major site of synthesis of the IGFs, from where they enter the blood stream, thereby acting in a classical endocrine fashion. A wide variety of body cells express IGF receptors, of which there are two types. Furthermore, IGFs are also synthesized in smaller quantities at numerous sites in the body and function in an autocrine or paracrine manner at these specific locations. IGF activity is also modulated by a family of IGFBPs, of which there are at least six. [Pg.281]

SEM = standard error of the means. IGF-I = insulin-like growth factor I. [Pg.412]

Insulin and Amylin. Insulin is a member of a family of related peptides, the insulin-like growth factors (IGFs), including IGF-I and IGF-II (60) and amylin (75), a 37-amino acid peptide that mimics the secretory pattern of insulin. Amylin is deficient ia type 1 diabetes meUitus but is elevated ia hyperinsulinemic states such as insulin resistance, mild glucose iatolerance, and hypertension (33). Insulin is synthesized ia pancreatic P cells from proinsulin, giving rise to the two peptide chains, 4. and B, of the insulin molecule. IGF-I and IGF-II have stmctures that are homologous to that of proinsulin (see INSULIN AND OTHER ANTIDIABETIC DRUGS). [Pg.555]

Insulin-like growth factor Angio tensino gen Leptin Ghrelin... [Pg.8]

Bouaboula, M., Perrachon, S., Milligan, L., Canatt, X., Rinaldi-Carmona, M., Portier, M., Barth, F., Calandra, B., Pecceu, F., Lupker, J., Maffrand, J.-P., Le Fur, G., and Casellas, P. (1997). A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor. J. Biol. Ckem. 272 22330-22339. [Pg.58]

In addition to insulin, the INSR can also bind insulin-like growth factors (IGF1 and IGF2) albeit with considerably lower affinity (2 and 3 orders of magnitude, respectively). [Pg.632]

Studies with fenretinide in woman with stage I breast cancer did not show an overall effect of decreasing the risk of contralateral breast cancer. A protective effect could only be observed in premenopausal women, probably due to the modulation of the insulin-like growth factor 1 (IGF-1) by fenretinide in this population. [Pg.1076]

Insulin Desensitization Insulin Receptor Insulin Resistance Insulin Secretagogues Insulin-like Growth Factor Integrase Integrin, a 4(31 Integrin, a 4(3 7 Integrin, a IIb(3 3... [Pg.1494]

ANF Atrial natriuretic factor IGF-I Insulin-like growth factor-I... [Pg.434]

Insulin-like growth factors I and II Nerve growth factor Platelet-derived growth factor Prolactin... [Pg.437]

ARJMANDI B H, KHALIL D A and HOLLIS B w (2002), Soy protein its effects on intestinal calcium transport, serum vitamin D and insulin-like growth factor-1 in ovariectomized rats. Calcif Tissue Int 70(6), 483-7. [Pg.101]

KHALIL D A, LUCAS E A, lUMA S, SMITH B J, PAYTON M E and ARJMANDI B H (2002) Soy prOteiu supplementation increases serum insulin-like growth factor-1 in young and old men but does not affect markers of bone metabolism. J Nutr 132, 2605-8. [Pg.103]

Karas, M. et ah. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells, Nutr. Cancer, 36,101, 2000. [Pg.144]

G-CSF Granulocyte colony-stimulating factor GDP Guanosine 5 -diphosphate GEC Glomerular epithelial cell GF-1 An insulin-like growth factor GFR Glomerular filtration rate... [Pg.282]

Immunoglobulins A, E, G, M IgG I Immunc obulin G class 1 IgGa, Immunoglobulin G class 2a IGF-I Insulin-like growth factor Ig-SF Immunoglobulin supergene family... [Pg.283]

Fahrner, R.L., Lester, P.M., Blank, G.S., and Reifsnyder, D. H., Non-flammable preparative reversed-phase liquid chromatography of recombinant human insulin-like growth factor-I, ]. Chromatogr. A, 830, 127, 1999. [Pg.138]

Pegvisomant is indicated for patients who do not tolerate or fail other treatments or for those with extremely elevated insulin-like growth factor I levels. [Pg.701]

Dopamine agonists may be appropriate for patients with mildly elevated insulin-like growth factor I levels who have growth hormone and prolactin co-secreting tumors. [Pg.701]

Prolonged exposure to elevated growth hormone and insulin-like growth factor I levels can lead to serious complications in patients with acromegaly. Aggressively manage... [Pg.701]

GH, growth hormone Gl, gastrointestinal IGF-I, insulin-like growth factor I IM, intramuscularly LAR, long-acting release MRI, magnetic resonance imaging SQ, subcutaneously. [Pg.708]

IGFBP-3 insulin-like growth factor binding protein 3... [Pg.720]

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Autoradiography insulin-like growth factors

Diabetes mellitus insulin-like growth factors

Human insulin-like growth factor

Insulin like growth factors signaling

Insulin-like factors

Insulin-like growth factor 1 (IGF

Insulin-like growth factor 1 receptor (IGF

Insulin-like growth factor 2 receptor gene

Insulin-like growth factor I (IGF

Insulin-like growth factor I receptor

Insulin-like growth factor X-ray crystallographic studies

Insulin-like growth factor amino acid sequence

Insulin-like growth factor binding protein

Insulin-like growth factor diabetes effects

Insulin-like growth factor embryo

Insulin-like growth factor expression

Insulin-like growth factor hypoglycemia

Insulin-like growth factor mecasermin)

Insulin-like growth factor receptor family

Insulin-like growth factor receptor interleukin

Insulin-like growth factor receptors modulation

Insulin-like growth factor targeting

Insulin-like growth factor therapy

Insulin-like growth factor tissue

Insulin-like growth factor-II

Insulin-like growth factor-binding protein IGFBP)

Insulin-like growth factor-mediated signal

Insulin-like growth factors IGF-binding protein

Insulin-like growth factors IGFs)

Insulin-like growth factors Subject

Insulin-like growth factors biological effects

Insulin-like growth factors gene expression

Insulin-like growth factors neurotrophic role

Insulin-like growth factors synthesis

Insuline-like growth factor

Insuline-like growth factor

Like Growth Factor

Neurons insulin-like growth factors

Plasmid insulin-like growth factor

Receptor insulin-like growth factor

Renal effects, insulin-like growth factors

Serum insulin-like growth factor

Somatomedins: insulin-like growth factors

Somatomedins: insulin-like growth factors binding proteins

Treatment insulin-like growth factors

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