P38 mitogen-activated protein kinase

Kampen GT, Stafford S, Adachi T, et al. Eotaxin induces degranulation and che-motaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 2000 95(6) 1911-1917. 

Knall C, Worthen GS, Johnson GL. Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases. Proc Natl Acad Sci U S A 1997 94(7) 3052-3057. 

Arima, H., Yamamoto, N., Sobue, K. etal. Hyperosmolar mannitol simulates expression of aquaporins 4 and 9 through a p38 mitogen-activated protein kinase-dependent pathway in rat astrocytes. /. Biol. Chem. 278 44525-44534,... 

Fiebich, B. L., Schleicher, S., Spleiss, O., Czygan, M. and Hull, M. Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. /. Neurochem. 5 950-958,2001. 

Mori-Abe A, Tsutsumi S, Takahashi K, Toya M, Yoshida M, Du B, Kawagoe J, Naka-hara K, Takahashi T, Ohmichi M, Kurachi H (2003) Estrogen and raloxifene induce apoptosis by activating p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells. J Endocrinol 178 417-426... 

Arrighi, J.F.et al., A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J. Immunol., 166, 3837, 2001. 

Aiba, S. et al., p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiC12 and 2,4-dinitrochlorobenzene, J. Invest. Dermatol., 120, 390, 2003. 

Benhar, M. et al., Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress, Mol. Cell. Biol., 21, 6913, 2001. 

Chung, Y. J., Zhou H.R., and Pestka J.J. Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin). Toxicol. Appl. Pharmacol. 193,188, 2003. 

Shifrin, V. I. and Anderson P. Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J. Biol. Chem. 274, 13985, 1999. 

Kozawa, O., Niwa, M., Matsuno, H., Tokuda, H., Miwa, M., Ito, H., Kato, K. Uematsu, T., 1999a, Sphingosine 1 -phosphate induces heat shock protein 27 via p38 mitogen-activated protein kinase activation in osteoblasts, 7. Bone. Min. Res. 14 1761-1767. 

Hamuro Y, Coales S.J., Morrow J., Griffin P.R., Southern M.R., Weber P.C. Application of hydrogen/ deuterium-exchange to p38 mitogen-activated protein kinase. Am. Biotechnol. Lab. (in press). 

McCaffrey P.G., Chambers S.P., Su M.S.-S. Crystal structure of p38 mitogen-activated protein kinase. 

Davis, T., Baird, D. M., Haughton, M. F., Jones, C. J., and Kipling, D. (2005). Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. J. Gerontol. A Biol. Sci. Med. Sci. 60,1386-1393. 

Reproduced with permission from Zhang, J. R, Wong, C. K., and Lam, C. W. K. Role of caspases in dexamethasone-induced apoptosis and activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase in human eosinophils. Clin. Exp. Immunol. 122,20-27 (2000) and Blackwell Science Ltd. 

G5. Graves, J. D., Draves, K. E., Craxton, A., Saklatvala, J., Krebs, E. G., and Clark, E. A., Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 93, 13814— 13818 (1996). 

Kawasaki, H., Morooka, T., Shimohama, S., Kimura, J., Hirano, T., Gotoh, Y., and Nishida, E., Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J. Biol. Chem. Ill, 18518-18521 (1997). 

Pedersen IM, Buhl AM, Klausen P et al. The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell ehronie lymphoeytie leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism. B/oo[Pg.226]

Diep, Q. N., Touyz, R. M., and Schiffrin, E. L. (2000). Docosahexaenoic acid, a peroxisome proliferator-activated receptors-a ligand induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension 36, 851-855. 

Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD (2004) Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Mol Pharmacol 65(6) 1462-1474... 

Hnia K, Hugon G, Rivier F, Masmoudi A, Mercier J, Momet D (2007) Modulation of p38 mitogen-activated protein kinase cascade and metalloproteinase activity in diaphragm muscle in response to free radical scavenger administration in dystrophin deficient Mdx mice. Am... 

Anter E, Chen K, Shapira OM, Karas RH, Keaney JF Jr. 2005. p38 mitogen activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols. Circ Res 96 1072-1078. 

Svensson C. I., Marsala M., Westerlund A., Calcutt N. A., Campana W. M., Freshwater J. D., Catalano R., Feng Y., Proffer A. A., Scott B., and Yaksh T. L. (2003b). Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J. Neurochem. 86 1534-1544. 

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