P42/44 mitogen-activated protein kinase

Carrillo, J.J. Ibares, B. Esteban-Gamboa, A. Feliu, J.E. Involvement of both phosphatidylinositol 3-kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin. Endocrinology, 142, 1057-1064 (2001)... 

English, J. D., and Sweatt, J. D. (1996). Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. J. Biol. Chem. 271, 24329-24332. 

PAPKOFF J, Chen R-H, BLENIS J, FORSMAN J. p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are sriecdvely phosphorylated and activated during thrombin-induced platelet activation and aggregation. Mol Cdl Biol 14 463-472,1994. 

Post GR, Goldstein D, Thuerauf DJ, Glembotski CC, Brown JH. Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes. J Biol Chem 1996 271 8452-8457. 

McGahon B, Maguire C, Kelly A, Lynch MA. Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1.3-dicarboxylate impacts on long-term potentiation in the dentate gyms in the rat analysis of age-related changes. Neiu oscience 1999 90 1167-1176. 

Nagata T, Kansha M, Irita K, Takahashi S. Propofol inhibits FMLP-stimulated phosphorilation of p42 mitogen-activated protein kinase and chemotaxix in human neutrophils. Brit J Anaesth 2001 86 853-8. 

Alderton, F.A., Darroch, P.I., Sambi, B., McKie, A., Pyne, N.J. and Pyne, S., 2001, G-protein-coupled receptor signaling to p42/p44 mitogen-activated protein kinase is attenuated by Upid phosphate phosphatases 1,1a and 2 in HEK 293 cells, J. Biol. Chem. 276 13452-13460. 

Rakhit, S., Conway, A-M., Tate, R., Bower, T, Pyne, N.J. and Pyne, S., 1999, Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle role of endothelial differentiation gene-1, c-Src tyrosine kinase and phosphoinositide 3-kinase. Biochem. J. 338 643-649. 

Geraldes R Sirois MG, Bernatchez PN, Tanguay JE Estrogen regulation of endothelial and smooth muscle cell migration and proliferation role of p38 and p42/44 mitogen-activated protein kinase. Arterioscler Thromb Vase Biol 2002 22 1585-1590. 

Goppelt-Struebe M, Hahn A, Stroebel M, Reiser CO. Independent regulation of cyclo-oxygenase 2 expression by p42/44 mitogen-activated protein kinases and Ca2+/calmodulin-dependent kinase. Biochem J 1999 339(Pt 2) 329-334. 

Iwasaki H, Eguchi S, Ueno H, Marumo F, Hirata Y. 1999. Endothelin-mediated vascular growth requires p42/p44 mitogen-activated protein kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptorl. Endocrinology 140 4659-4668. 

Wheeler-Jones, C., Abu-Ghazaleh, R., Cospedal, R., Houliston, R. A., Martin, J., and Zachary, I. 1997. Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase. FEBS Lett. 420 28-32. 

Gripentrog, J. M., Jesaitis, A. J., and Miettinen, H. M. (2000). A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis. Biochem. J. 352(Pt 2), 399-407. 

PAF activates mitogen activated protein kinase (MAP Kinase) in platelets. PAF stimulated P42 MAP Kinase lAPK) in sheep platelets and to a lesser extent P44 MAPK. S6 kinases were also stimulated by PAF (Sa ei et. al., 1993). It is likely that PKC is involved in fiiis process. However, any precise role for platelet MAPK in PAF responses awaits future investigation. 

Kobayashi Y, Arai S, Waku K, Sugiura T (2001) Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. J Biochem (Tokyo) 129 665-669... 

Majka, M., Ratajczak, J., et al. (2000). Binding of stromal derived factor-lalpha (SDF-lalpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT. Eur J Haematol 64(3) 164—72. 

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