P38 mitogen-activated protein kinase MAPK

Genetically modified mice either overexpressing or knocking out specific components have provided exciting advances in our knowledge of diseases. Recently, we focused on the p38 mitogen-activated protein kinase (MAPK) pathway and its physiological effect on inflammation. 

Krump, E., Sanghera, J.S., Pelech, S.L., Furuya, W. and Grinstein, S. (1997). Chemotactic peptide N-formyl-Met-Leu-Phe acbvabon of p38 mitogen-activated protein kinase (MAPK) and MAPK-acbvated protein kinase-2 in human neutrophils./. Biol. Chem. 272, 937-944. 

Some cytokines. The IL-6 class cytokine oncostatin M (OSM), IL-1 and TNFa of monocyte-macrophage derivation are activators of the jak gene and thus the JAK/STAT and/or JAK/MAPK pathways in fibroblast-like synoviocytes of RA. These cells overproduce BL-6 and MMPs, harbor an activated JAK gene, and allow intranuclear translocation of the phosphoiylated STAT protein dimers. The specific inhibitor of OSM, CP690,550 may reverse the entire process. The p38 mitogen-activated protein kinase (MAPK) with the member of its group, the c-Jun... 

At the same time, two important intracellular signalling proteins involved in the nuclear translocation of nuclear factor erythroid-derived 2 Nfe2] such as the extracellular signal-regulated protein kinases (ERKs), and the p38 mitogen-activated protein kinase (MAPK) of a class of mitogen-activated protein kinases that are responsive to their stress stimuli such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock were also activated. 

Seko Y, Takahashi N, Tobe K, Kadowaki T, Vazaki Y. Hypoxia and hypoxia/ reoxygenation activate p65PAK, p38 mitogen-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes. Biochem Biophys Res Commun 1997 239 840-844. 

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