Receptor tyrosine kinases activation

Molecnles that Interfere with Receptor Tyrosine Kinase Activity... 

LiNASSiER c, PIERRE M, LE PECQ J B and PIERRE J (1990) Mechanism of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity. Biochem Pharmacol. 39 (1) 187-93. 

Wouters, F. S. and Bastiaens, P. I. H. (1999). Fluorescence lifetime imaging of receptor tyrosine kinase activity in cells. Curr. Biol. 9, 1127-30. 

Increased p42/p44 MAPK Increased c-jun and c-fos Increased non-receptor tyrosine kinase activity-increased phospholipase C Increased p38 MAPK Reduced cAMP Increased NO and NOS... 

Davis RJ, Czech MP. Amiloride inhibits growth factor receptor tyrosine kinase activity. J Cell Biol 1985 260 2543-2551. 

Liu, S. M., and G. Carpenter. Differential heat stress stability of epidermal growth factor receptor and erbB-2 receptor tyrosine kinase activities. J-Cell-Physiol. 157 237-42.1993. 

Chakravorty, A. Joslyn, M.L Davis, J.S. Characterization of insulin and insulin-like growth factor-I actions in the bovine luteal cell Regulation of receptor tyrosine kinase activity, phosphatidylinositol 3-kinase, and deoxyribonucleic acid synthesis. Endocrinology, 133, 1331-1340 (1993)... 

Wilden, P.A. Kahn, C.R. The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases. Mol. Endocrinol., 8, 558-567 (1994)... 

I Insulin binding activates I receptor tyrosine kinase activity in the intracellular domain of the 3 subunit of the insulin receptor. 

Cheng, N., Brantley, D. M., Liu, H., Lin, Q., Enriquez, M., et al. 2002. Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol. Cancer Res. 1 2-11. 

Inhibition of the epidermal growth factor receptor tyrosine kinase activity by Leflunomide. FEBS Lett. 334,161-164. 

G. S. Hotamisligil, P. Peraldi, A. Budavari, R Ellis, M. F. White and B. M. Spic eiman. IRS-l-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science, 271 (5249), 665-668, 1996. 

Schlessinger J. How receptor tyrosine kinases activate Ras. Trends Biochem Sci 1993 18 273-275. 

Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. 2000. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96 925-32... 

In Xenopus o(x es (126,134), treatment with metformin has been shown to increase insulin receptor tyrosine kinase activity associated with activation of phospholipase C and increased levels of IPg and intracellular Ca. Thus metformin, through increasing receptor tyrosine kinase activity, may facilitate IRS protein phosphorylation and activation of phosphatidylinositol-3-kinase, leading to increased glucose uptake. 

Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK (2003) Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci USA 100 9330-9335... 

Insulin binding activates receptor tyrosine kinase activity and earn phorylation cascade that modulates various intracellular proteins. Fo insulin binding inhibits hormone-sensitive lipase in adipocytes. It appa so by activating a phosphatase that dephosphorylates the lipase. In adi... 

The RET receptor tyrosine kinase activation, signalling and significance in neural development and disease... 

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