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P38 mitogen-activated protein kinase MAPK pathway

Genetically modified mice either overexpressing or knocking out specific components have provided exciting advances in our knowledge of diseases. Recently, we focused on the p38 mitogen-activated protein kinase (MAPK) pathway and its physiological effect on inflammation. [Pg.218]

Some cytokines. The IL-6 class cytokine oncostatin M (OSM), IL-1 and TNFa of monocyte-macrophage derivation are activators of the jak gene and thus the JAK/STAT and/or JAK/MAPK pathways in fibroblast-like synoviocytes of RA. These cells overproduce BL-6 and MMPs, harbor an activated JAK gene, and allow intranuclear translocation of the phosphoiylated STAT protein dimers. The specific inhibitor of OSM, CP690,550 may reverse the entire process. The p38 mitogen-activated protein kinase (MAPK) with the member of its group, the c-Jun... [Pg.97]

See other pages where P38 mitogen-activated protein kinase MAPK pathway is mentioned: [Pg.374]    [Pg.127]    [Pg.309]    [Pg.195]    [Pg.374]    [Pg.127]    [Pg.309]    [Pg.195]    [Pg.737]    [Pg.283]    [Pg.263]    [Pg.145]    [Pg.436]    [Pg.11]    [Pg.123]    [Pg.196]    [Pg.98]    [Pg.628]    [Pg.203]    [Pg.283]    [Pg.223]    [Pg.455]    [Pg.456]    [Pg.43]    [Pg.2183]    [Pg.509]    [Pg.15]    [Pg.65]    [Pg.500]    [Pg.540]    [Pg.457]    [Pg.724]    [Pg.18]    [Pg.216]    [Pg.174]    [Pg.95]    [Pg.211]    [Pg.386]    [Pg.26]    [Pg.215]    [Pg.123]    [Pg.540]    [Pg.103]    [Pg.574]    [Pg.284]    [Pg.54]    [Pg.358]    [Pg.23]    [Pg.237]    [Pg.428]    [Pg.432]    [Pg.220]   
See also in sourсe #XX -- [ Pg.218 ]



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Kinase activated

Kinase activity

Kinase p38 MAPK

Kinase, kinases pathway

MAPKs

Mitogen-activated

Mitogen-activated kinase

Mitogen-activated protein

Mitogen-activated protein kinase

Mitogen-activated protein kinase mitogens

Mitogen-activated protein kinase pathway

Mitogen-activated protein kinases MAPKs)

Mitogen-activated protein kinases activation

P38 MAPK

P38 MAPK pathways

P38 kinase

P38 mitogen-activated protein kinase MAPK)

P38 pathway

Protein kinase activation

Protein kinase pathways

Protein mitogens

Protein pathway

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