Mitogen-activated protein kinase pharmacological

Li S, Wattenberg EV, Differential activation of mitogen-activated protein kinases by palytoxin and ouabain, two ligands for the Na , K -ATPase, Toxicology and Applied Pharmacology 151 377-384, 1998. 

The significance of CD phosphorylation is further evidenced by the work of Adam et al. (1995b), which demonstrated that the level of mitogen-activated protein kinase (MAPK), the enzyme presumably involved in CD phosphorylation in vivo, is regulated in response to both mechanical load and pharmacological stimulation. Further work will likely delineate the precise role of CD phosphorylation in smooth muscle. 

Dai Y, Yu C, Singh V et al. (2001) Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/ MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells. Cancer Res 61 5106-5115... 

Rizzo, M., and Romero, G. (2002). Pharmacological importance of phosphohpase D and phosphatidic acid in the regulation of the mitogen-activated protein kinase cascade. Pharmacol. Ther. 94, 35-50. 

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